Universität zu Köln

Dias, Irundika H. K., Milic, Ivana ORCID: 0000-0001-7531-7561, Heiss, Christian ORCID: 0000-0002-3212-8995, Ademowo, Opeyemi S., Polidori, Maria Cristina, Devitt, Andrew ORCID: 0000-0002-4651-6761 and Griffiths, Helen R. (2020). Inflammation, Lipid (Per)oxidation, and Redox Regulation. Antioxid. Redox Signal., 33 (3). S. 166 - 191. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1557-7716

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Abstract

Recent Advances: Inflammation is central to age-related decline in health and exhibits a complex relationship with mitochondrial redox state and metabolic function. Improvements in mass spectrometric methods have led to the identification of families of oxidized phospholipids (OxPLs), cholesterols, and fatty acids that increase during inflammation and which modulate nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor gamma (PPAR gamma), activator protein 1 (AP1), and NF-kappa B redox-sensitive transcription factor activity. Critical Issues: The kinetic and spatial resolution of the modified lipidome has profound and sometimes opposing effects on inflammation, promoting initiation at high concentration and resolution at low concentration of OxPLs. Future Directions: There is an emerging opportunity to prevent or delay age-related inflammation and vascular comorbidity through a resolving (oxy)lipidome that is dependent on improving mitochondrial quality control and restoring redox homeostasis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dias, Irundika H. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Milic, Ivana UNSPECIFIED orcid.org/0000-0001-7531-7561 UNSPECIFIED Heiss, Christian UNSPECIFIED orcid.org/0000-0002-3212-8995 UNSPECIFIED Ademowo, Opeyemi S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Polidori, Maria Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Devitt, Andrew UNSPECIFIED orcid.org/0000-0002-4651-6761 UNSPECIFIED Griffiths, Helen R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-343808
DOI:	10.1089/ars.2020.8022
Journal or Publication Title:	Antioxid. Redox Signal.
Volume:	33
Number:	3
Page Range:	S. 166 - 191
Date:	2020
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1557-7716
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIOVASCULAR-DISEASE MORTALITY; AGE-ASSOCIATED CHANGES; A(4) STABLE ANALOGS; OXIDIZED PHOSPHOLIPIDS; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; DOCOSAHEXAENOIC ACID; LIPOXIN A(4); APOPTOTIC NEUTROPHILS; ENDOTHELIAL-CELLS Multiple languages Biochemistry & Molecular Biology; Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34380