Universität zu Köln

Schwarzenberger, Anke, Hasselmann, Martin ORCID: 0000-0003-3305-4024 and Von Elert, Eric (2020). Positive selection of digestive proteases in Daphnia: A mechanism for local adaptation to cyanobacterial protease inhibitors. Mol. Ecol., 29 (5). S. 912 - 920. HOBOKEN: WILEY. ISSN 1365-294X

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Abstract

Due to the combined effects of global warming and eutrophication, the frequency of deleterious cyanobacterial blooms in freshwater ecosystems has increased. In line with this, local adaptation of the aquatic keystone herbivore Daphnia to cyanobacteria has received major attention. Besides microcystins, the most frequent cyanobacterial secondary metabolites in such blooms are protease inhibitors (PIs). Recently, it has been shown that a protease gene showed copy number variation between four D. magna populations that differed in tolerance to PIs. From that study, we chose two distinct populations of D. magna which had or had not coexisted with cyanobacteria in the past. By calculating F-ST values, we found that the two populations were genetically more distant in the protease loci than in neutral loci. Population genetic tests applied to the tolerant population revealed that positive selection was most probably acting on the gene loci of the digestive protease CT448 and CT802. We conclude that the selection of digestive proteases and subsequent reduction in copy number is the molecular basis of evolutionary changes leading to local adaptation to PIs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schwarzenberger, Anke UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasselmann, Martin UNSPECIFIED orcid.org/0000-0003-3305-4024 UNSPECIFIED Von Elert, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-343868
DOI:	10.1111/mec.15375
Journal or Publication Title:	Mol. Ecol.
Volume:	29
Number:	5
Page Range:	S. 912 - 920
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-294X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STATISTICAL TESTS; NEUTRALITY; GENE; MAGNA; LIMITATION; TOLERANCE; FREQUENCY; VERSION Multiple languages Biochemistry & Molecular Biology; Ecology; Evolutionary Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34386