Universität zu Köln

Wieland, Ulrike, Oellig, Frank and Kreuter, Alexander (2020). Anal dysplasia and anal cancer. Hautarzt, 71 (4). S. 284 - 293. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1173

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Abstract

Anal intraepithelial neoplasia (AIN) and 89-100% of anal cancers are caused by persistent infections with high-risk (HR) human papillomaviruses (HPV). In HIV-positive patients, anal HPV infection and AIN are very common and these patients have a greatly increased risk of developing anal cancer. However, a continuous increase in the incidence of anal cancer has also been observed in the general population in recent decades. AIN can clinically present in diverse manners. In HIV-positive patients AIN can be hidden in condylomas. Furthermore, 3-14% of high-grade AIN progress to anal cancer within 5 years. Therefore, screening examinations should be offered to patients with an increased risk for anal cancer. The treatment options for AIN are similar to those for condylomas. HIV-positive patients with controlled immune status and HIV-negative patients with anal cancer respond comparably well to combined radiochemotherapy. A German-language AWMF S3 guideline for anal cancer will be available in 2020. In HIV-positive patients over 26 years of age, HPV vaccination showed no effect in a controlled phase-3 study. To prevent AIN and anal cancer in the future, HPV vaccination rates need to be increased in HPV-naive girls and boys.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wieland, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Oellig, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuter, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-344707
DOI:	10.1007/s00105-020-04548-9
Journal or Publication Title:	Hautarzt
Volume:	71
Number:	4
Page Range:	S. 284 - 293
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1173
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIV-POSITIVE MEN; HUMAN-PAPILLOMAVIRUS INFECTION; CETUXIMAB PLUS CHEMORADIOTHERAPY; SQUAMOUS-CELL CARCINOMA; INTRAEPITHELIAL NEOPLASIA; HPV INFECTION; RISK-FACTORS; UNITED-STATES; SEX; PREVALENCE Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34470