Wieland, Ulrike, Oellig, Frank and Kreuter, Alexander (2020). Anal dysplasia and anal cancer. Hautarzt, 71 (4). S. 284 - 293. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1173

Full text not available from this repository.

Abstract

Anal intraepithelial neoplasia (AIN) and 89-100% of anal cancers are caused by persistent infections with high-risk (HR) human papillomaviruses (HPV). In HIV-positive patients, anal HPV infection and AIN are very common and these patients have a greatly increased risk of developing anal cancer. However, a continuous increase in the incidence of anal cancer has also been observed in the general population in recent decades. AIN can clinically present in diverse manners. In HIV-positive patients AIN can be hidden in condylomas. Furthermore, 3-14% of high-grade AIN progress to anal cancer within 5 years. Therefore, screening examinations should be offered to patients with an increased risk for anal cancer. The treatment options for AIN are similar to those for condylomas. HIV-positive patients with controlled immune status and HIV-negative patients with anal cancer respond comparably well to combined radiochemotherapy. A German-language AWMF S3 guideline for anal cancer will be available in 2020. In HIV-positive patients over 26 years of age, HPV vaccination showed no effect in a controlled phase-3 study. To prevent AIN and anal cancer in the future, HPV vaccination rates need to be increased in HPV-naive girls and boys.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wieland, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oellig, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreuter, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-344707
DOI: 10.1007/s00105-020-04548-9
Journal or Publication Title: Hautarzt
Volume: 71
Number: 4
Page Range: S. 284 - 293
Date: 2020
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1432-1173
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HIV-POSITIVE MEN; HUMAN-PAPILLOMAVIRUS INFECTION; CETUXIMAB PLUS CHEMORADIOTHERAPY; SQUAMOUS-CELL CARCINOMA; INTRAEPITHELIAL NEOPLASIA; HPV INFECTION; RISK-FACTORS; UNITED-STATES; SEX; PREVALENCEMultiple languages
DermatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34470

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item