Juche, A., Siegert, E., Mueller-Ladner, U., Riemekasten, G., Guenther, C., Koetter, I, Henes, J., Blank, N., Voll, R. E., Ehrchen, J., Schmalzing, M., Susok, L., Schmeiser, T., Sunderkoetter, C., Distler, J., Worm, M., Kreuter, A., Horvath, N., Schoen, M. P., Korsten, P., Zeidler, G., Pfeiffer, C., Krieg, T., Hunzelmann, N. and Moinzadeh, P. . Reality of inpatient vasoactive treatment with prostacyclin derivatives in patients with acral circulation disorders due to systemic sclerosis in Germany. Z. Rheumatol.. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1435-1250

Full text not available from this repository.

Abstract

Background Raynaud's phenomenon and the frequently ensuing digital ulcerations represent an early and very distressing symptom in patients with systemic sclerosis (scleroderma, SSc) causing significant limitations in the ability to work and quality of life. The use of vasoactive drugs (especially intravenous prostacyclin derivatives) is recommended to reduce the risk of hypoxic tissue damage up to the loss of fingers. Methods In order to obtain information about the current state of treatment of patients with prostacyclin derivatives in routine clinical life in Germany, a survey was conducted among the centers affiliated to the German Network for Systemic Scleroderma (DNSS). In addition, a separate patient survey was conducted by the schleroderma self-help group (Sklerodermie Selbsthilfe e.& x202f;V.), which only covered the symptoms Raynaud's syndrome, digital ulcers and the use of intravenous prostacyclin derivatives. Results Of the 433 patients surveyed 56% stated that they had already been treated with prostacyclin derivatives (iloprost/alprostadil) because of their illness and symptoms. A total of 61% received the treatment for severe Raynaud's phenomenon and 39% for digital ulcerations. Most respondents not only experienced an improvement in Raynaud & apos;s phenomenon and digital ulcers but also a significant improvement of limitations in everyday life. They also needed significantly less outside help and absenteeism from work was much lower. Conclusion Patients consistently reported a positive effect of treatment with prostacyclin derivatives on Raynaud & apos;s phenomenon, acral ulcerations, pain and daily restrictions and felt well and safely cared for during inpatient treatment. These positive effects in the patients & apos; perceptions provide crucial information supporting and confirming the current European and international treatment recommendations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Juche, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siegert, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Ladner, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riemekasten, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guenther, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koetter, IUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henes, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blank, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Voll, R. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehrchen, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmalzing, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Susok, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmeiser, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sunderkoetter, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Distler, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Worm, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreuter, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horvath, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoen, M. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korsten, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeidler, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeiffer, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krieg, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunzelmann, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moinzadeh, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-345095
DOI: 10.1007/s00393-019-00743-9
Journal or Publication Title: Z. Rheumatol.
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1435-1250
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DIGITAL ULCERS; DOUBLE-BLIND; BOSENTAN; ILOPROST; PREDICT; RISKMultiple languages
RheumatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34509

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item