Universität zu Köln

Poeschla, Michael and Valenzano, Dario R. (2020). The turquoise killifish: a genetically tractable model for the study of aging. J. Exp. Biol., 223. CAMBRIDGE: COMPANY BIOLOGISTS LTD. ISSN 1477-9145

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Abstract

Lifespan is a remarkably diverse trait in nature, ranging from just hours in adult mayflies to hundreds of years in the Greenland shark and quahog clam. Great disparities in lifespan are often observed even among somewhat closely related species; for example, in the laboratory, wild-derived strains of the common house mouse have a maximum observed lifespan of approximately 6 years, while a similarly sized rodent, the naked mole rat, can live for over 30 years. Comparative biology of aging across the tree of life provides a tremendous opportunity for understanding the molecular and genetic basis underlying lifespan and aging. However, a lack of molecular and laboratory tools has limited the ability of researchers to take full advantage of the incredible diversity of aging phenotypes in nature. Recent developments in genomic technology have made it increasingly possible to study non-canonical model organisms for aging. One promising new genetic model organism amenable to a range of experimental interventions is the turquoise killifish (Nothobranchius furzeri). This fish species has a naturally short lifespan and undergoes a wide range of aging-related transformations. These fish have a fully sequenced genome and transcriptome, and killifish embryos are accessible to transgenesis and genome editing. Furthermore, different killifish species and populations show striking differences in lifespan, providing the opportunity for comparative analysis of aging. This Review introduces the natural life history of the turquoise killifish, its emerging applicability as an aging model system, the genetic tools that have been developed to study aging for this species and a summary of recent studies facilitated by these new tools.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Poeschla, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Valenzano, Dario R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-345775
DOI:	10.1242/jeb.209296
Journal or Publication Title:	J. Exp. Biol.
Volume:	223
Date:	2020
Publisher:	COMPANY BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9145
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AGE-RELATED MARKERS; LIFE-SPAN; NOTHOBRANCHIUS-FURZERI; ANNUAL FISH; VERTEBRATE MODEL; EVOLUTION; LONGEVITY; DIAPAUSE; HISTORY; GENOME Multiple languages Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34577