Universität zu Köln

Di Cristanziano, Veronica, Weimer, Kristina, Boettcher, Sindy, Sarfo, Fred Stephen, Dompreh, Albert, Cesar, Lucio-Garcia, Knops, Elena ORCID: 0000-0001-7398-3026, Heger, Eva, Wirtz, Maike, Kaiser, Rolf, Norman, Betty, Phillips, Richard Odame, Feldt, Torsten and Eberhardt, Kirsten Alexandra (2020). Molecular Characterization and Clinical Description of Non-Polio Enteroviruses Detected in Stool Samples from HIV-Positive and HIV-Negative Adults in Ghana. Viruses-Basel, 12 (2). BASEL: MDPI. ISSN 1999-4915

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Abstract

In the post-polio eradication era, increasing attention is given to non-polio enteroviruses. Most of the data about enteroviruses in sub-Saharan Africa are related to acute flaccid paralysis surveillance and target the pediatric population. This study aimed to investigate the presence of enterovirus in PLHIV (people living with HIV) and HIV-negative individuals in Ghana. Stool samples from HIV-positive individuals (n = 250) and healthy blood donors (n = 102) attending the Komfo Anokye Teaching Hospital in Kumasi, Ghana, were screened by real-time PCR for enterovirus. Molecular typing of the VP1 region was performed. Enterovirus-positive samples were tested for norovirus, adenovirus, rotavirus, sapovirus, and cosaviruses. Twenty-six out of 250 HIV-positive subjects (10.4%) and 14 out of 102 HIV-negative individuals (13.7%) were detected enterovirus-positive, not showing a significant different infection rate between the two groups. HIV-negative individuals were infected with Enterovirus C strains only. HIV-positive participants were detected positive for species Enterovirus A, Enterovirus B, and Enterovirus C. Co-infections with other viral enteric pathogens were almost exclusively detected among HIV-positive participants. Overall, the present study provides the first data about enteroviruses within HIV-positive and HIV-negative adults living in Ghana.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED Weimer, Kristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Boettcher, Sindy UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarfo, Fred Stephen UNSPECIFIED UNSPECIFIED UNSPECIFIED Dompreh, Albert UNSPECIFIED UNSPECIFIED UNSPECIFIED Cesar, Lucio-Garcia UNSPECIFIED UNSPECIFIED UNSPECIFIED Knops, Elena UNSPECIFIED orcid.org/0000-0001-7398-3026 UNSPECIFIED Heger, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirtz, Maike UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Norman, Betty UNSPECIFIED UNSPECIFIED UNSPECIFIED Phillips, Richard Odame UNSPECIFIED UNSPECIFIED UNSPECIFIED Feldt, Torsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Eberhardt, Kirsten Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-346103
DOI:	10.3390/v12020221
Journal or Publication Title:	Viruses-Basel
Volume:	12
Number:	2
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1999-4915
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CENTRAL-NERVOUS-SYSTEM; BACTERIAL MICROBIOME; COSAVIRUS INFECTION; HIGH-FREQUENCY; IMMUNODEFICIENCY; CHILDREN; PERSISTENT; CAMEROON; VIROME; SOUTH Multiple languages Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34610