Universität zu Köln

Clahsen, Thomas, Buettner, Christian, Hatami, Niloofar, Reis, Andre ORCID: 0000-0002-6301-6363 and Cursiefen, Claus (2020). Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation. J. Clin. Med., 9 (2). BASEL: MDPI. ISSN 2077-0383

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Abstract

Under normal conditions, the cornea, being the transparent windscreen of the eye, is free of both blood and lymphatic vessels. However, various diseases of the eye, like infections, can interfere with the balance between promoting and inhibiting factors, which leads to ingrowth of blood and lymphatic vessels. The newly formed lymphatic vessels increase the risk of graft rejection after subsequent corneal transplantation. Corneal transplantation is one of the most commonly performed transplantations worldwide, with more than 40,000 surgeries per year in Europe. To date, various anti-hem- and anti-lymphangiogenic treatment strategies have been developed specifically for the corneal vascular endothelial growth factor (VEGF) pathway. Currently, however, no treatment strategies are clinically available to specifically modulate lymphangiogenesis. In this review, we will give an overview about endogenous regulators of hem- and lymphangiogenesis and discuss potential new strategies for targeting pathological lymphangiogenesis. Furthermore, we will review recently identified modulators and demonstrate that the cornea is a suitable model for the identification of novel endogenous modulators of lymphangiogenesis. The identification of novel modulators of lymphangiogenesis and a better understanding of the signaling pathways involved will contribute to the development of new therapeutic targets for the treatment of pathological lymphangiogenesis. This, in turn, will improve graft rejection, not only for the cornea.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Clahsen, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hatami, Niloofar UNSPECIFIED UNSPECIFIED UNSPECIFIED Reis, Andre UNSPECIFIED orcid.org/0000-0002-6301-6363 UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-346334
DOI:	10.3390/jcm9020479
Journal or Publication Title:	J. Clin. Med.
Volume:	9
Number:	2
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-FACTOR RECEPTOR-3; NONCODING RNA; TOPICAL BEVACIZUMAB; VEGF-C; MATRIX METALLOPROTEINASES; GENETIC-HETEROGENEITY; LYMPHATIC VESSELS; TYROSINE KINASES; DOWN-REGULATION; GRAFT-SURVIVAL Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34633