Universität zu Köln

Mettler, Jasmin, Armefti, Stella, Schmidt, Matthias, Faust, Michael, Engels, Marianne and Chiapponi, Costanza (2020). Benign Thyroid Diseases: Are There Gender-Specific Differences for Diagnosis and Treatment of Nontoxic Thyroid Nodules? Results from a 4-Year Retrospective Analysis of an Endocrine Tumor Board. Visc. Med., 36 (1). S. 28 - 34. BASEL: KARGER. ISSN 2297-475X

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Abstract

Introduction: Benign nodular goiters are endemic in Germany and diagnostic thyroidectomy is one of the most frequent surgical procedures. Less than 10% result in a malignant finding which is a poor ratio in comparison to other European countries. There is a female preponderance in almost all thyroid pathologies according to the current literature but not much is known concerning gender-specific differences in thyroid nodules. Objective: We aimed at finding gender-specific differences in diagnosis and treatment of nontoxic thyroid nodules and focused on preoperative workup as well as cytological and histological findings of patients with solitary and multinodular nontoxic goiters. Methods: We retrospectively analyzed 392 cases out of 693 thyroid cases managed interdisciplinarily by the endocrine board of a university center between January 2015 and December 2018 (4 years). Results: The combination of fine needle biopsy and interdisciplinary case discussion resulted in a rate of malignancy of 28.9% in patients undergoing surgery for solitary and multinodular nontoxic goiter. Although there was no significant gender-specific difference in the distributions and malignancy rates of Bethesda categories, male patients had a significantly higher malignancy rate of 40% in our collective (p = 0.04). Conclusions: Surgical treatment for male patients with suspicious hypofunctioning thyroid nodules should be favored. However, well-designed prospective studies are required to investigate gender-specific recommendations for the treatment of benign thyroid diseases in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mettler, Jasmin UNSPECIFIED UNSPECIFIED UNSPECIFIED Armefti, Stella UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Faust, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Engels, Marianne UNSPECIFIED UNSPECIFIED UNSPECIFIED Chiapponi, Costanza UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-346396
DOI:	10.1159/000505499
Journal or Publication Title:	Visc. Med.
Volume:	36
Number:	1
Page Range:	S. 28 - 34
Date:	2020
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	2297-475X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MANAGEMENT; AGE Multiple languages Gastroenterology & Hepatology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34639