Universität zu Köln

Skoetz, Nicole, Goldkuhle, Marius, van Dalen, Elvira C., Akl, Elie A., Trivella, Marialena, Mustafa, Reem A., Nowak, Artur, Dahm, Philipp, Schunemann, Holger and Bender, Ralf (2020). GRADE guidelines 27: how to calculate absolute effects for time-to-event outcomes in summary of findings tables and Evidence Profiles. J. Clin. Epidemiol., 118. S. 124 - 132. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-5921

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Abstract

Objectives: To provide GRADE guidance on how to prepare Summary of Findings tables and Evidence Profiles for time-to-event outcomes with a focus on the calculation of the corresponding absolute effect estimates. Study Design and Setting: This guidance was justified by a research project identifying frequent errors and limitations in the presentation of time-to-event outcomes in the Summary of Findings tables. We developed this guidance through an iterative process that included membership consultation, feedback, presentation, and discussion at meetings of the GRADE Working Group. Results: Review authors need to carefully consider the definition of the outcome of interest; although often the event is used as label for the outcome of interest (e.g., death or mortality), the event-free survival (e.g., overall survival) is reported throughout individual studies. Review authors should calculate the absolute effect correctly, either for the event or absence of the event. We also provide examples on how to calculate the absolute effects for events and the absence of events for various baseline or control group risks and time points. Conclusions: This article aids in the development of Summary of Findings tables and Evidence Profiles, including time-to-event outcomes, and addresses the most common scenarios when calculating absolute effects in order to provide an accurate interpretation. (C) 2019 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Skoetz, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldkuhle, Marius UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dalen, Elvira C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Akl, Elie A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Trivella, Marialena UNSPECIFIED UNSPECIFIED UNSPECIFIED Mustafa, Reem A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nowak, Artur UNSPECIFIED UNSPECIFIED UNSPECIFIED Dahm, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Schunemann, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-347697
DOI:	10.1016/j.jclinepi.2019.10.015
Journal or Publication Title:	J. Clin. Epidemiol.
Volume:	118
Page Range:	S. 124 - 132
Date:	2020
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-5921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERVAL ESTIMATION; TREAT; DIFFERENCE Multiple languages Health Care Sciences & Services; Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34769