Universität zu Köln

Firner, Sara, Zaucke, Frank, Heilig, Juliane, de Marees, Markus, Willwacher, Steffen, Brueggemann, Gert-Peter and Niehoff, Anja ORCID: 0000-0002-4165-0929 (2020). Impact of knee joint loading on fragmentation of serum cartilage oligomeric matrix protein. J. Orthop. Res., 38 (8). S. 1710 - 1719. HOBOKEN: WILEY. ISSN 1554-527X

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Abstract

The aim of the study was to examine the effect of mechanical knee joint loading on the fragmentation pattern of serum cartilage oligomeric matrix protein (COMP). Ten healthy men ran with knee orthoses that were passive or active (+30.9 N center dot m external flexion moments) on a treadmill (30 minute; v = 2.2 m/s). Lower-limb mechanics, serum COMP levels, and fragmentation patterns (baseline; 0, 0.5, 1, 2 hours postrunning) were analyzed. Running with active orthoses enhanced knee flexion moments, ankle dorsiflexion, and knee flexion angles (P < .05). There was an increase in serum COMP (+25%; pre: 8.9 +/- 2.4 U/l; post: 10.7 +/- 1.9 U/l, P = .001), COMP pentamer/tetramer (+88%; 1.88 +/- 0.81, P = .007), trimer (+209%; 3.09 +/- 2.65, P = .005), and monomer (+78%; 1.78 +/- 0.85, P = .007) after running with passive orthoses and in serum COMP (+41%; pre: 8.5 +/- 2.7 U/l; post: 11.3 +/- 2.1 U/l, P < .001), COMP pentamer/tetramer (+57%; 1.57 +/- 0.39, P = .007), trimer (+86%; 1.86 +/- 0.47, P = .005), and monomer (+19%; 1.19 +/- 0.34, P = .114) after running with active orthoses. Increased fragmentation might indicate COMP release from cartilage while running. Interestingly, 0.5 h up to 2 hours after running with passive orthoses, trimer (0.5 hour: 2.73 +/- 3.40, P = .029; 2 hours: 2.33 +/- 2.88, P = .037), and monomer (0.5 hour: 2.23 +/- 2.33, P = .007; 1 hour: 2.55 +/- 1.96, P = .012; 2 hours: 2.65 +/- 2.50, P = .009) increased while after running with active orthoses, pentamer/tetramer (1 hour: 0.79 +/- 0.28, P = .029), and trimer (1 hour: 0.63 +/- 0.14, P = .005; 2 hours: 0.68 +/- 0.34, P = .047) decreased. It seems that COMP degradation and clearance vary depending on joint loading characteristics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Firner, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaucke, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Heilig, Juliane UNSPECIFIED UNSPECIFIED UNSPECIFIED de Marees, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Willwacher, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Brueggemann, Gert-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Niehoff, Anja UNSPECIFIED orcid.org/0000-0002-4165-0929 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-348856
DOI:	10.1002/jor.24586
Journal or Publication Title:	J. Orthop. Res.
Volume:	38
Number:	8
Page Range:	S. 1710 - 1719
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1554-527X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ARTICULAR-CARTILAGE; SYNOVIAL-FLUID; COMP; OSTEOARTHRITIS; LIGAMENT; DEGRADATION; INJURY; METALLOPROTEINASE; ASSOCIATIONS; EXPRESSION Multiple languages Orthopedics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34885