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P., Chang-Claude, Jenny, Garcia-Closas, Montserrat, Schmidt, Marjanka K., Milne, Roger L., Kristensen, Vessela N., French, Juliet D., Edwards, Stacey L., Antoniou, Antonis C., Chenevix-Trench, Georgia ORCID: 0000-0002-1878-2587, Simard, Jacques, Easton, Douglas F., Kraft, Peter, Dunning, Alison M., Mari, Veronique, Berthet, Pascaline, Castera, Laurent ORCID: 0000-0002-0459-3400, Vaur, Dominique ORCID: 0000-0003-2792-8506, Lallaoui, Hakima, Bignon, Yves-Jean, Uhrhammer, Nancy, Bonadona, Valerie, Lasset, Christine, Revillion, Francoise, Vennin, Paul, Muller, Daniele, Gomes, Denise Molina, Ingster, Olivier, Coupier, Isabelle, Pujol, Pascal, Collonge-Rame, Marie-Agnes, Mortemousque, Isabelle, Bera, Odile, Rose, Mickaelle, Baurand, Amandine, Bertolone, Geoffrey, Faivre, Laurence, Dreyfus, Hlne, Leroux, Dominique, Venat-Bouvet, Laurence, Bezieau, Stephane, Delnatte, Capucine, Chiesa, Jean, Gilbert-Dussardier, Brigitte, Gesta, Paul, Prieur, Fabienne Prieur, Bronner, Myriam, Sokolowska, Johanna, Coulet, Florence, Boutry-Kryza, Nadia, Calender, Alain, Giraud, Sophie, Leone, Melanie, Fert-Ferrer, Sandra, Jiao, Yue, Lesueur, Fabienne Lesueur, Barouk-Simonet, Emmanuelle, Bubien, Virginie, Longy, Michel, Sevenet, Nicolas, Gladieff, Laurence, Toulas, Christine, Reimineras, Audrey, Sobol, Hagay, Bressac-de Paillerets, Brigitte, Cabaret, Odile, Caron, Olivier, Guillaud-Bataille, Marine, Rouleau, Etienne, Belotti, Muriel, Buecher, Bruno, Caputo, Sandrine ORCID: 0000-0001-5338-9388, Colas, Chrystelle, De Pauw, Antoine, Fourme, Emmanuelle, Gauthier-Villars, Marion, Golmard, Lisa, Moncoutier, Virginie, Saule, Claire, Donaldson, Alan, Murray, Alex, Brady, Angela, Brewer, Carole, Pottinger, Caroline, Miller, Clare, Gallagher, David, Gregory, Helen, Cook, Jackie, Eason, Jacqueline, Adlard, Julian, Barwell, Julian, Ong, Kai-Ren, Snape, Katie, Walker, Lisa, Izatt, Louise, Side, Lucy, Rogers, Mark T., Porteous, Mary E., Ahmed, Munaza, Morrison, Patrick J., Brennan, Paul, Eeles, Ros, Davidson, Rosemarie, Sexton, Adrienne, Christian, Alice, Trainer, Alison, Spigelman, Allan, Fellows, Andrew, Shelling, Andrew, De Fazio, Anna, Blackburn, Anneke, Crook, Ashley, Meiser, Bettina, Patterson, Briony, Clarke, Christine, Hunt, Clare, Scott, Clare, Amor, David, Marsh, Deb, Edkins, Edward, Salisbury, Elizabeth, Haan, Eric, Neidermayr, Eveline, Macrea, Finlay, Farshid, Gelareh, Lindeman, Geoff, Trench, Georgia, Mann, Graham, Giles, Graham, Gill, Grantley, Thorne, Heather, Hickie, Ian, Winship, Ingrid, Flanagan, James ORCID: 0000-0003-4955-1383, Kollias, James, Visvader, Jane, Taylor, Jessica, Burke, Jo, Saunus, Jodi, Forbes, John, Hopper, John, French, Juliet ORCID: 0000-0002-9770-0198, Tucker, Kathy, Wu, Kathy, Phillips, Kelly, Lipton, Lara, Andrews, Leslie, Lobb, Lizz, Walker, Logan, Kentwell, Maira, Spurdle, Mandy, Cummings, Margaret, Gleeson, Margaret, Harris, Marion, Jenkins, Mark, Young, Mary Anne, Delatycki, Martin, Wallis, Mathew, Burgess, Matthew, Price, Melanie, Brown, Melissa, Southey, Melissa, Bogwitz, Michael, Field, Michael, Friedlander, Michael, Gattas, Michael, Saleh, Mona, Hayward, Nick, Pachter, Nick, Cohen, Paul ORCID: 0000-0002-4860-9232, Duijf, Pascal, James, Paul ORCID: 0000-0002-4361-4657, Simpson, Pete, Fong, Peter, Butow, Phyllis, Williams, Rachael, Kefford, Rick, Scott, Rodney, Milne, Roger, Balleine, Rosemary, Dawson, SarahJane, Lok, Sheau, O'Connell, Shona, Greening, Sian, Nightingale, Sophie, Edwards, Stacey, Fox, Stephen, Mclachlan, Sue-Anne, Lakhani, Sunil, Antill, Yoland, Aalfs, Cora, Meijers-Heijboer, Hanne, van Engelen, Klaartje, Gille, Hans, Boere, Ingrid, Collee, Margriet, van Deurzen, Carolien, Hooning, Maartje, Obdeijn, Inge-Marie, van den Ouweland, Ans, Seynaeve, Caroline, Siesling, Sabine, Verloop, Janneke, van Asperen, Christi, van Cronenburg, Twiggy, Blok, Rien, de Boer, Maaike, Garcia, Encarna Gomez, Adank, Muriel, Hogervorst, Frans, Jenner, Denise, van Leeuwen, Flora, Rookus, Matti, Russell, Nicola, Schmidt, Marjanka, van den Belt-Dusebout, Sandra, Kets, Carolien, Mensenkamp, Arjen ORCID: 0000-0003-3805-877X, de Bock, Truuske, van Der Hout, Annemieke, Mourits, Marian, Oosterwijk, Jan, Ausems, Margreet, Koudijs, Marco, Marsh, Deborah, Baxter, Robert, Yip, Desmond ORCID: 0000-0002-2806-2401, Carpenter, Jane, Davis, Alison, Pathmanathan, Nirmala, Simpson, Peter, Graham, Dinny and Sachchithananthan, Mythily (2020). Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nature Genet., 52 (1). NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1718

Full text not available from this repository.

Abstract

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions. Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched genomic features to determine variants with high posterior probabilities of being causal. Potentially causal variants were significantly over-represented in active gene regulatory regions and transcription factor binding sites. We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. Known cancer drivers, transcription factors and genes in the developmental, apoptosis, immune system and DNA integrity checkpoint gene ontology pathways were over-represented among the highest-confidence target genes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Fachal, LauraUNSPECIFIEDorcid.org/0000-0002-7256-9752UNSPECIFIED
Aschard, HuguesUNSPECIFIEDorcid.org/0000-0002-7554-6783UNSPECIFIED
Beesley, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barnes, Daniel R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allen, JamieUNSPECIFIEDorcid.org/0000-0002-8677-2225UNSPECIFIED
Kar, SiddharthaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pooley, Karen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dennis, JoeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michailidou, KyriakiUNSPECIFIEDorcid.org/0000-0001-7065-1237UNSPECIFIED
Turman, ConstanceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soucy, PennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lemacon, AudreyUNSPECIFIEDorcid.org/0000-0002-1817-7029UNSPECIFIED
Lush, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tyrer, Jonathan P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghoussaini, MayaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marjaneh, Mahdi MoradiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jiang, XiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agata, SimonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aittomaki, KristiinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosario Alonso, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrulis, Irene L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anton-Culver, HodaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonenkova, Natalia N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arason, AdalgeirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arndt, VolkerUNSPECIFIEDorcid.org/0000-0001-9320-8684UNSPECIFIED
Aronson, Kristan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arun, Banu K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Auber, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Auer, Paul L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azzollini, JacopoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balmana, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barkardottir, Rosa B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrowdale, DanielUNSPECIFIEDorcid.org/0000-0003-1661-3939UNSPECIFIED
Beeghly-Fadiel, AliciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benitez, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bermisheva, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bialkowska, KatarzynaUNSPECIFIEDorcid.org/0000-0001-8489-6665UNSPECIFIED
Blanco, Amie M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blomqvist, CarlUNSPECIFIEDorcid.org/0000-0003-3041-1938UNSPECIFIED
Blot, WilliamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bogdanova, Natalia, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bojesen, Stig E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bolla, Manjeet K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonanni, BernardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borg, AkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bosse, KristinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brauch, HiltrudUNSPECIFIEDorcid.org/0000-0001-7531-2736UNSPECIFIED
Brenner, HermannUNSPECIFIEDorcid.org/0000-0002-6129-1572UNSPECIFIED
Briceno, IgnacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brock, Ian W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brooks-Wilson, AngelaUNSPECIFIEDorcid.org/0000-0003-1009-6408UNSPECIFIED
Bruening, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burwinkel, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Cai, QiuyinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caldes, TrinidadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caligo, Maria A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Canzian, FedericoUNSPECIFIEDorcid.org/0000-0002-4261-4583UNSPECIFIED
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Christiansen, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chung, Wendy K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Claes, Kathleen B. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clarke, Christine L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collee, J. MargrietUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornelissen, StenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Couch, Fergus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cox, AngelaUNSPECIFIEDorcid.org/0000-0002-5138-1099UNSPECIFIED
Cross, Simon S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cybulski, CezaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czene, KamilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daly, Mary B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de la Hoya, MiguelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devilee, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diez, OrlandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ding, Yuan ChunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dite, Gillian S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Domchek, Susan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doerk, ThiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
dos-Santos-Silva, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Droit, ArnaudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dubois, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dumont, MartineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Durcan, LorraineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Guenel, PascalUNSPECIFIEDorcid.org/0000-0002-8359-518XUNSPECIFIED
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Hall, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamann, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harrington, Patricia A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Hartman, MikaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
He, WeiUNSPECIFIEDorcid.org/0000-0003-0161-3274UNSPECIFIED
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Heemskerk-Gerritsen, Bernadette A. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heyworth, JaneUNSPECIFIEDorcid.org/0000-0003-1411-4554UNSPECIFIED
Hillemanns, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogervorst, Frans B. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hollestelle, AntoinetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hooning, Maartje J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Jager, AgnesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Coulet, FlorenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Calender, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giraud, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leone, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fert-Ferrer, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jiao, YueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lesueur, Fabienne LesueurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barouk-Simonet, EmmanuelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bubien, VirginieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Longy, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sevenet, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Sobol, HagayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bressac-de Paillerets, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cabaret, OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caron, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guillaud-Bataille, MarineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rouleau, EtienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Belotti, MurielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buecher, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caputo, SandrineUNSPECIFIEDorcid.org/0000-0001-5338-9388UNSPECIFIED
Colas, ChrystelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Pauw, AntoineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fourme, EmmanuelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gauthier-Villars, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Golmard, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moncoutier, VirginieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saule, ClaireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Donaldson, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murray, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brady, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brewer, CaroleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pottinger, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miller, ClareUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallagher, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gregory, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cook, JackieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eason, JacquelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adlard, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barwell, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ong, Kai-RenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Snape, KatieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Izatt, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Side, LucyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rogers, Mark T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Porteous, Mary E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahmed, MunazaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morrison, Patrick J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brennan, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eeles, RosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davidson, RosemarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sexton, AdrienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Christian, AliceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trainer, AlisonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spigelman, AllanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fellows, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shelling, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Fazio, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blackburn, AnnekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crook, AshleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meiser, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patterson, BrionyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clarke, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunt, ClareUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scott, ClareUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amor, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marsh, DebUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Edkins, EdwardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salisbury, ElizabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haan, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neidermayr, EvelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Macrea, FinlayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farshid, GelarehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindeman, GeoffUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trench, GeorgiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mann, GrahamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giles, GrahamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gill, GrantleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thorne, HeatherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hickie, IanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winship, IngridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flanagan, JamesUNSPECIFIEDorcid.org/0000-0003-4955-1383UNSPECIFIED
Kollias, JamesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visvader, JaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, JessicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burke, JoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saunus, JodiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Forbes, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
French, JulietUNSPECIFIEDorcid.org/0000-0002-9770-0198UNSPECIFIED
Tucker, KathyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wu, KathyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phillips, KellyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lipton, LaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrews, LeslieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lobb, LizzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, LoganUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kentwell, MairaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spurdle, MandyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cummings, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gleeson, MargaretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harris, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenkins, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Young, Mary AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delatycki, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallis, MathewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgess, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Price, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brown, MelissaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southey, MelissaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bogwitz, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Field, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedlander, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gattas, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saleh, MonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hayward, NickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pachter, NickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cohen, PaulUNSPECIFIEDorcid.org/0000-0002-4860-9232UNSPECIFIED
Duijf, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
James, PaulUNSPECIFIEDorcid.org/0000-0002-4361-4657UNSPECIFIED
Simpson, PeteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fong, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Butow, PhyllisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, RachaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kefford, RickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scott, RodneyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milne, RogerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balleine, RosemaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dawson, SarahJaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lok, SheauUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Connell, ShonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greening, SianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nightingale, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Edwards, StaceyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fox, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mclachlan, Sue-AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lakhani, SunilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antill, YolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aalfs, CoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meijers-Heijboer, HanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Engelen, KlaartjeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gille, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boere, IngridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collee, MargrietUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Deurzen, CarolienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hooning, MaartjeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obdeijn, Inge-MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Ouweland, AnsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seynaeve, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siesling, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verloop, JannekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Asperen, ChristiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Cronenburg, TwiggyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blok, RienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Boer, MaaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia, Encarna GomezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adank, MurielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogervorst, FransUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenner, DeniseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Leeuwen, FloraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rookus, MattiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russell, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, MarjankaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Belt-Dusebout, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kets, CarolienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mensenkamp, ArjenUNSPECIFIEDorcid.org/0000-0003-3805-877XUNSPECIFIED
de Bock, TruuskeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Der Hout, AnnemiekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mourits, MarianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oosterwijk, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ausems, MargreetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koudijs, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marsh, DeborahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baxter, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yip, DesmondUNSPECIFIEDorcid.org/0000-0002-2806-2401UNSPECIFIED
Carpenter, JaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davis, AlisonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pathmanathan, NirmalaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simpson, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graham, DinnyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachchithananthan, MythilyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-349158
DOI: 10.1038/s41588-019-0537-1
Journal or Publication Title: Nature Genet.
Volume: 52
Number: 1
Date: 2020
Publisher: NATURE PUBLISHING GROUP
Place of Publication: NEW YORK
ISSN: 1546-1718
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; COMPREHENSIVE MOLECULAR PORTRAITS; ESTROGEN-RECEPTOR; INTEGRATIVE ANALYSIS; FUNCTIONAL VARIANTS; SUSCEPTIBILITY LOCI; PROTEIN FUNCTION; CHROMATIN; ENHANCER; REVEALSMultiple languages
Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/34915

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