Universität zu Köln

Behnke, Verena, Wolf, Anne ORCID: 0000-0003-2551-9821 and Langmann, Thomas (2020). The role of lymphocytes and phagocytes in age-related macular degeneration (AMD). Cell. Mol. Life Sci., 77 (5). S. 781 - 789. BASEL: SPRINGER BASEL AG. ISSN 1420-9071

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Abstract

Age-related macular degeneration (AMD) is a leading cause of visual impairment of the elderly population. Since AMD is a multifactorial age-related disease with various genetic risk factors, the understanding of its complex pathophysiology is still limited. However, animal experiments, genome-wide association data and the molecular profiling of AMD patient samples have highlighted a key role of systemic and local immune processes that contribute to this chronic eye disease. In this overview article, we concentrate on the role of lymphocytes and mononuclear phagocytes and their interplay in triggering a persistent immune response in the AMD retina. We preferentially review findings from human immune cell analyses and complement these with related findings in experimental models. We conclude that both immune cell types as their signaling network may be a rich source to identify novel molecular targets for immunomodulation in AMD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Behnke, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Anne UNSPECIFIED orcid.org/0000-0003-2551-9821 UNSPECIFIED Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-349373
DOI:	10.1007/s00018-019-03419-4
Journal or Publication Title:	Cell. Mol. Life Sci.
Volume:	77
Number:	5
Page Range:	S. 781 - 789
Date:	2020
Publisher:	SPRINGER BASEL AG
Place of Publication:	BASEL
ISSN:	1420-9071
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHOROIDAL NEOVASCULARIZATION; T-CELLS; SUBRETINAL INFLAMMATION; EXPRESSION; MONOCYTES; ACTIVATION; MEMBRANE; RECEPTOR; ACCUMULATION; LEUKOCYTES Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34937