Universität zu Köln

Leta, Valentina, van Wamelen, Daniel J., Sauerbier, Anna ORCID: 0000-0003-0966-5933, Jones, Shelley, Parry, Miriam, Rizos, Alexandra and Chaudhuri, K. Ray (2020). Opicapone and Levodopa-Carbidopa Intestinal Gel Infusion: The Way Forward Towards Cost Savings for Healthcare Systems? J. Parkinsons Dis., 10 (4). S. 1535 - 1540. AMSTERDAM: IOS PRESS. ISSN 1877-718X

Full text not available from this repository.

Abstract

Combined catechol-O-methyl-transferase-inhibition and Levodopa-Carbidopa intestinal gel (LCIG) infusion has the potential to reduce LCIG daily dose and the costs of this therapy. In this retrospective analysis, we report on Parkinson's disease (PD) patients on LCIG with concomitant Opicapone. In 11 patients, the introduction of Opicapone led to LCIG daily dose being reduced by 24.8% (p = 0.05) without any significant worsening of dyskinesia. Three patients withdrew from Opicapone due to side effects or inefficacy. LCIG daily dose reduction could lead to cost savings of 142,820.63 pound/year in the United Kingdom while maintaining clinical care.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Leta, Valentina UNSPECIFIED UNSPECIFIED UNSPECIFIED van Wamelen, Daniel J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sauerbier, Anna UNSPECIFIED orcid.org/0000-0003-0966-5933 UNSPECIFIED Jones, Shelley UNSPECIFIED UNSPECIFIED UNSPECIFIED Parry, Miriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Rizos, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaudhuri, K. Ray UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-349707
DOI:	10.3233/JPD-202022
Journal or Publication Title:	J. Parkinsons Dis.
Volume:	10
Number:	4
Page Range:	S. 1535 - 1540
Date:	2020
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1877-718X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PARKINSONS-DISEASE; MOTOR FLUCTUATIONS; ENTACAPONE; THERAPY; ADJUNCT Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34970