Universität zu Köln

Chen, Guanqun ORCID: 0000-0002-8133-834X, Liu, Chunhua, Yang, Kun, Li, Yuxia, Sheng, Can, Xie, Yunyan, Hu, Xiaochen, Jiang, Jiehui and Han, Ying (2020). Beneficial Effects of Brain Reserve on Cognition in Individuals with Subjective Cognitive Decline from the SILCODE Study. J. Alzheimers Dis., 75 (4). S. 1203 - 1211. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: Clinical research has demonstrated that brain reserve (BR) could exert positive effects on cognition for patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, the effects of BR on cognition in individuals with subjective cognitive decline (SCD) are not clear. Objective: To examine cross-sectional effects of BR on cognition in SCD populations. Methods: One hundred forty-nine subjects were studied from the Sino Longitudinal Study on Cognitive Decline (SILCODE) study. Head circumference was used as a proxy of BR. Cognition was assessed across four domains (memory, executive, language, and general cognitive functions). Multiple linear regression models were conducted to examine effects of BR on cognitive scores. Furthermore, we addressed the question that whether the degree of self-perception of cognitive decline modified the effect of BR on cognitive performance in SCD subjects. Results: We found a positive effect of BR on language cognition in subjects with SCD. Furthermore, the positive effect of BR on language cognition survived in SCD participants with a low degree of self-perception of cognitive decline while disappeared in SCD participants with a high degree of self-perception of cognitive decline. Conclusion: This study suggests that BR has the potential to delay or slow down cognitive decline in SCD individuals, especially for mild SCD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chen, Guanqun UNSPECIFIED orcid.org/0000-0002-8133-834X UNSPECIFIED Liu, Chunhua UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Kun UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Yuxia UNSPECIFIED UNSPECIFIED UNSPECIFIED Sheng, Can UNSPECIFIED UNSPECIFIED UNSPECIFIED Xie, Yunyan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Xiaochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Jiang, Jiehui UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Ying UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-350536
DOI:	10.3233/JAD-200005
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	75
Number:	4
Page Range:	S. 1203 - 1211
Date:	2020
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INCIDENT ALZHEIMERS-DISEASE; HEAD CIRCUMFERENCE; NATIONAL INSTITUTE; AMYLOID PATHOLOGY; DEMENTIA; IMPAIRMENT; NEUROPATHOLOGY; ASSOCIATIONS; PREVALENCE; GUIDELINES Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35053