Universität zu Köln

Sebeke, Lukas Christian, Rademann, Pia, Maul, Alexandra Claudia, Schubert-Quecke, Claudia ORCID: 0000-0001-6591-387X, Annecke, Thorsten, Yeo, Sin Yuin, Castillo-Gomez, Juan Daniel, Schmidt, Patrick ORCID: 0000-0003-0170-0247, Grull, Holger ORCID: 0000-0002-0993-9300 and Heijman, Edwin (2020). Feasibility study of MR-guided pancreas ablation using high-intensity focused ultrasound in a healthy swine model. Int. J. Hyperthermia, 37 (1). S. 786 - 799. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1464-5157

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Abstract

Purpose:Pancreatic cancer is typically diagnosed in a late stage with limited therapeutic options. For those patients, ultrasound-guided high-intensity focused ultrasound (US-HIFU) can improve local control and alleviate pain. However, MRI-guided HIFU (MR-HIFU) has not yet been studied extensively in this context. To facilitate related research and accelerate clinical translation, we report a workflow for thein vivoHIFU ablation of the porcine pancreas under MRI guidance. Materials and methods:The pancreases of five healthy German landrace pigs (35-58 kg) were sonicated using a clinical MR-HIFU system. Acoustic access to the pancreas was supported by a specialized diet and a hydrogel compression device for bowel displacement. Organ motion was suspended using periods of apnea. The size of the resulting thermal lesions was assessed using the thermal threshold- and dose profiles, non-perfused volume, and gross examination. The effect of the compression device on beam path length was assessed using MRI imaging. Results:Eight of ten treatments resulted in clearly visible damage in the target tissue upon gross examination. Five treatments resulted in coagulative necrosis. Good agreement between the four metrics for lesion size and a clear correlation between the delivered energy dose and the resulting lesion size were found. The compression device notably shortened the intra-abdominal beam path. Conclusions:We demonstrated a workflow for HIFU treatment of the porcine pancreas in-vivo under MRI-guidance. This development bears significance for the development of MR-guided HIFU interventions on the pancreas as the pig is the preferred animal model for the translation of pre-clinical research into clinical application.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sebeke, Lukas Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Rademann, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Maul, Alexandra Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schubert-Quecke, Claudia UNSPECIFIED orcid.org/0000-0001-6591-387X UNSPECIFIED Annecke, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Yeo, Sin Yuin UNSPECIFIED UNSPECIFIED UNSPECIFIED Castillo-Gomez, Juan Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Patrick UNSPECIFIED orcid.org/0000-0003-0170-0247 UNSPECIFIED Grull, Holger UNSPECIFIED orcid.org/0000-0002-0993-9300 UNSPECIFIED Heijman, Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-350577
DOI:	10.1080/02656736.2020.1782999
Journal or Publication Title:	Int. J. Hyperthermia
Volume:	37
Number:	1
Page Range:	S. 786 - 799
Date:	2020
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1464-5157
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IN-VIVO; THERMAL DOSIMETRY; TISSUE VOLUME; PAIN RELIEF; CANCER; THERAPY; ADENOCARCINOMA; GEMCITABINE; EXPERIENCE; FIXATION Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35057