Sebeke, Lukas Christian, Rademann, Pia, Maul, Alexandra Claudia, Schubert-Quecke, Claudia ORCID: 0000-0001-6591-387X, Annecke, Thorsten, Yeo, Sin Yuin, Castillo-Gomez, Juan Daniel, Schmidt, Patrick ORCID: 0000-0003-0170-0247, Grull, Holger ORCID: 0000-0002-0993-9300 and Heijman, Edwin (2020). Feasibility study of MR-guided pancreas ablation using high-intensity focused ultrasound in a healthy swine model. Int. J. Hyperthermia, 37 (1). S. 786 - 799. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1464-5157

Full text not available from this repository.

Abstract

Purpose:Pancreatic cancer is typically diagnosed in a late stage with limited therapeutic options. For those patients, ultrasound-guided high-intensity focused ultrasound (US-HIFU) can improve local control and alleviate pain. However, MRI-guided HIFU (MR-HIFU) has not yet been studied extensively in this context. To facilitate related research and accelerate clinical translation, we report a workflow for thein vivoHIFU ablation of the porcine pancreas under MRI guidance. Materials and methods:The pancreases of five healthy German landrace pigs (35-58 kg) were sonicated using a clinical MR-HIFU system. Acoustic access to the pancreas was supported by a specialized diet and a hydrogel compression device for bowel displacement. Organ motion was suspended using periods of apnea. The size of the resulting thermal lesions was assessed using the thermal threshold- and dose profiles, non-perfused volume, and gross examination. The effect of the compression device on beam path length was assessed using MRI imaging. Results:Eight of ten treatments resulted in clearly visible damage in the target tissue upon gross examination. Five treatments resulted in coagulative necrosis. Good agreement between the four metrics for lesion size and a clear correlation between the delivered energy dose and the resulting lesion size were found. The compression device notably shortened the intra-abdominal beam path. Conclusions:We demonstrated a workflow for HIFU treatment of the porcine pancreas in-vivo under MRI-guidance. This development bears significance for the development of MR-guided HIFU interventions on the pancreas as the pig is the preferred animal model for the translation of pre-clinical research into clinical application.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sebeke, Lukas ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rademann, PiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maul, Alexandra ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schubert-Quecke, ClaudiaUNSPECIFIEDorcid.org/0000-0001-6591-387XUNSPECIFIED
Annecke, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yeo, Sin YuinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castillo-Gomez, Juan DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, PatrickUNSPECIFIEDorcid.org/0000-0003-0170-0247UNSPECIFIED
Grull, HolgerUNSPECIFIEDorcid.org/0000-0002-0993-9300UNSPECIFIED
Heijman, EdwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-350577
DOI: 10.1080/02656736.2020.1782999
Journal or Publication Title: Int. J. Hyperthermia
Volume: 37
Number: 1
Page Range: S. 786 - 799
Date: 2020
Publisher: TAYLOR & FRANCIS LTD
Place of Publication: ABINGDON
ISSN: 1464-5157
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IN-VIVO; THERMAL DOSIMETRY; TISSUE VOLUME; PAIN RELIEF; CANCER; THERAPY; ADENOCARCINOMA; GEMCITABINE; EXPERIENCE; FIXATIONMultiple languages
Oncology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/35057

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item