Universität zu Köln

Ceccon, Garry, Wollring, Michael, Brunn, Anna, Deckert, Martina, Waldschmidt, Dirk, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Galldiks, Norbert ORCID: 0000-0002-2485-1796 (2020). Leptomeningeal Carcinomatosis in a Patient with Pancreatic Cancer Responding to Nab-Paclitaxel plus Gemcitabine. Case Rep. Oncol., 13 (1). S. 35 - 43. BASEL: KARGER. ISSN 1662-6575

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Abstract

Leptomeningeal carcinomatosis is an extremely rare, but devastating complication in pancreatic cancer patients with a poor prognosis despite multimodal treatment. We present a 51-year-old male patient with the very rare condition of leptomeningeal carcinomatosis originating from pancreatic cancer. He presented to our hospital with severe headache and neck stiffness 30 months after systemic chemotherapy. Cerebral and spinal MRI as well as cerebrospinal fluid examination confirmed the diagnosis of leptomeningeal carcinomatosis. The patient responded to gemcitabine plus nab-paclitaxel in terms of elimination of tumor cells from the CSF and concurrent clinical improvement for 3 months. The observed findings suggest that the combination of gemcitabine plus nab-paclitaxel is potentially effective in affected cerebrospinal fluid of pancreatic carcinoma patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ceccon, Garry UNSPECIFIED UNSPECIFIED UNSPECIFIED Wollring, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Brunn, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckert, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Waldschmidt, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-350853
DOI:	10.1159/000504697
Journal or Publication Title:	Case Rep. Oncol.
Volume:	13
Number:	1
Page Range:	S. 35 - 43
Date:	2020
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1662-6575
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALBUMIN-BOUND PACLITAXEL; BREAST-CANCER; PHASE-II; NEOPLASTIC MENINGITIS; NEOADJUVANT TRIAL; BRAIN; CHEMOTHERAPY; TRASTUZUMAB; COMBINATION; TUMOR Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35085