Universität zu Köln

Bebber, Christina M., Mueller, Fabienne, Clemente, Laura Prieto, Weber, Josephine and von Karstedt, Silvia (2020). Ferroptosis in Cancer Cell Biology. Cancers, 12 (1). BASEL: MDPI. ISSN 2072-6694

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Abstract

A major hallmark of cancer is successful evasion of regulated forms of cell death. Ferroptosis is a recently discovered type of regulated necrosis which, unlike apoptosis or necroptosis, is independent of caspase activity and receptor-interacting protein 1 (RIPK1) kinase activity. Instead, ferroptotic cells die following iron-dependent lipid peroxidation, a process which is antagonised by glutathione peroxidase 4 (GPX4) and ferroptosis suppressor protein 1 (FSP1). Importantly, tumour cells escaping other forms of cell death have been suggested to maintain or acquire sensitivity to ferroptosis. Therefore, therapeutic exploitation of ferroptosis in cancer has received increasing attention. Here, we systematically review current literature on ferroptosis signalling, cross-signalling to cellular metabolism in cancer and a potential role for ferroptosis in tumour suppression and tumour immunology. By summarising current findings on cell biology relevant to ferroptosis in cancer, we aim to point out new conceptual avenues for utilising ferroptosis in systemic treatment approaches for cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bebber, Christina M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Fabienne UNSPECIFIED UNSPECIFIED UNSPECIFIED Clemente, Laura Prieto UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Josephine UNSPECIFIED UNSPECIFIED UNSPECIFIED von Karstedt, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-351078
DOI:	10.3390/cancers12010164
Journal or Publication Title:	Cancers
Volume:	12
Number:	1
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLUTATHIONE-PEROXIDASE 4; TUMOR-ASSOCIATED MACROPHAGES; CYSTATHIONINE BETA-SYNTHASE; OXIDATIVE STRESS; CYSTINE/GLUTAMATE ANTIPORTER; DEATH RECOMMENDATIONS; TRANSCRIPTION FACTOR; LIPID-PEROXIDATION; MOUSE DEVELOPMENT; GENE-EXPRESSION Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/35107