Universität zu Köln

Escobar-Henriques, Mafalda ORCID: 0000-0002-0879-3119, Altin, Selver and den Brave, Fabian ORCID: 0000-0001-6955-4616 (2020). Interplay between the Ubiquitin Proteasome System and Mitochondria for Protein Homeostasis. Curr. Issues Mol. Biol., 35. S. 35 - 59. POOLE: CAISTER ACAD PRESS. ISSN 1467-3045

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Abstract

Eukaryotic cells are subdivided into membrane-bound compartments specialized in different cellular functions and requiring dedicated sets of proteins. Although cells developed compartment-specific mechanisms for protein quality control, chaperones and ubiquitin are generally required for maintaining cellular proteostasis. Proteotoxic stress is signalled from one compartment into another to adjust the cellular stress response. Moreover, transport of misfolded proteins between different compartments can buffer local defects in protein quality control. Mitochondria are special organelles in that they possess an own expression, folding and proteolytic machinery, of bacterial origin, which do not have ubiquitin. Nevertheless, the importance of extensive crosstalk between mitochondria and other subcellular compartments is increasingly clear. Here, we will present local quality control mechanisms and discuss how cellular proteostasis is affected by the interplay between mitochondria and the ubiquitin proteasome system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Escobar-Henriques, Mafalda UNSPECIFIED orcid.org/0000-0002-0879-3119 UNSPECIFIED Altin, Selver UNSPECIFIED UNSPECIFIED UNSPECIFIED den Brave, Fabian UNSPECIFIED orcid.org/0000-0001-6955-4616 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-352759
DOI:	10.21775/cimb.035.035
Journal or Publication Title:	Curr. Issues Mol. Biol.
Volume:	35
Page Range:	S. 35 - 59
Date:	2020
Publisher:	CAISTER ACAD PRESS
Place of Publication:	POOLE
ISSN:	1467-3045
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-CONTROL; MOLECULAR CHAPERONES; DAMAGED PROTEINS; AAA PROTEASES; CYTOSOLIC PROTEOSTASIS; ASYMMETRIC INHERITANCE; MISFOLDED PROTEINS; MEMBRANE PROTEINS; STRESS; YEAST Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/35275