Kreuzer, Martin, Pruefe, Jenny, Oldhafer, Martina, Bethe, Dirk, Dierks, Marie-Luise, Muether, Silvia, Thumfart, Julia ORCID: 0000-0003-1162-5295, Hoppe, Bernd, Buescher, Anja, Rascher, Wolfgang, Hansen, Matthias, Pohl, Martin, Kemper, Markus J., Drube, Jens, Rieger, Susanne, John, Ulrike, Taylan, Christina, Dittrich, Katalin, Hollenbach, Sabine, Klaus, Guenter, Fehrenbach, Henry, Kranz, Birgitta, Montoya, Carmen, Lange-Sperandio, Baerbel, Ruckenbrodt, Bettina, Billing, Heiko, Staude, Hagen, Heindl-Rusai, Krisztina, Brunkhorst, Reinhard and Pape, Lars ORCID: 0000-0002-3635-6418 (2015). Transitional Care and Adherence of Adolescents and Young Adults After Kidney Transplantation in Germany and Austria A Binational Observatory Census Within the TRANSNephro Trial. Medicine (Baltimore), 94 (48). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-5964

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Abstract

Transition from child to adult-oriented care is widely regarded a challenging period for young people with kidney transplants and is associated with a high risk of graft failure.We analyzed the existing transition structures in Germany and Austria using a questionnaire and retrospective data of 119 patients transferred in 2011 to 2012.Most centers (73%) confirmed agreements on the transition procedure. Patients' age at transfer was subject to regulation in 73% (18 years). Median age at transition was 18.3 years (16.5-36.7). Median serum creatinine increased from 123 to 132mol/L over the 12 month observation period before transfer (P=0.002). A total of 25/119 patients showed increased creatinine 20% just before transfer. Biopsy proven rejection was found in 10/119 patients. Three patients lost their graft due to chronic graft nephropathy.Mean coefficient of variation (CoV%) of immunosuppression levels was 0.200.1. Increased creatinine levels 20% just before transfer were less frequently seen in patients with CoV<0.20 (P=0.007).The majority of pediatric nephrology centers have internal agreements on transitional care. More than half of the patients had CoV of immunosuppression trough levels consistent with good adherence. Although, 20% of the patients showed increase in serum creatinine close to transfer.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kreuzer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pruefe, JennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oldhafer, MartinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bethe, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dierks, Marie-LuiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muether, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thumfart, JuliaUNSPECIFIEDorcid.org/0000-0003-1162-5295UNSPECIFIED
Hoppe, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buescher, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rascher, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansen, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pohl, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kemper, Markus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drube, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieger, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylan, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dittrich, KatalinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hollenbach, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klaus, GuenterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fehrenbach, HenryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kranz, BirgittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montoya, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lange-Sperandio, BaerbelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruckenbrodt, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Billing, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Staude, HagenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heindl-Rusai, KrisztinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunkhorst, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pape, LarsUNSPECIFIEDorcid.org/0000-0002-3635-6418UNSPECIFIED
URN: urn:nbn:de:hbz:38-384630
DOI: 10.1097/MD.0000000000002196
Journal or Publication Title: Medicine (Baltimore)
Volume: 94
Number: 48
Date: 2015
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1536-5964
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GRAFT FAILURE; HEALTH-CARE; MEDICATION ADHERENCE; BLOOD-LEVELS; REGIMEN; RISK; NONCOMPLIANCE; NONADHERENCE; VARIABILITY; PREVALENCEMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38463

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