Universität zu Köln

Duppre, Perrine, Sauer, Harald, Giannopoulou, Eleni Z., Gortner, Ludwig, Nunold, Holger, Wagenpfeil, Stefan, Geisel, Juergen, Stephan, Bernhard and Meyer, Sascha (2015). Cellular and humoral coagulation profiles and occurrence of IVH in VLBW and ELWB infants. Early Hum. Dev., 91 (12). S. 695 - 701. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-6232

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Abstract

Background and study purpose: Intraventricular hemorrhage (IVH) is a major complication in preterm neonates with significant long-term morbidity and an increased mortality rate. The role of the immature coagulation system in the pathogenesis of IVH in these infants is still under debate. The aim of this study was to provide reference values for coagulation studies within the first 24 h of life, and to relate these findings to the incidence of IVH. Patients and methods: In this retrospective study, a total of 250 (male: 123/female: 127; VLBW: 150 and ELBW: 100) infants were included over a 4-year-period. Coagulation studies were performed within the first 24 h of life in all infants. Multiple regression analysis was employed to demonstrate a potential association between IVH and a number of known risk and protective factors for IVH (antenatal steroids, birth weight, gender, IUGR, APGAR score at 10 minutes, platelet count, INR, PTT, fibrinogen). Results: Mean birth weight was 1047.9 +/- 305.6 (range: 320-1490 g). Both cellular (platelets, nucleated red blood cells) and plasmatic coagulation parameters (INR, fibrinogen and antithrombin III) were dependent on birth weight. Moreover, INR levels (p < 0.05) were significantly increased in neonates with IVH of any grade. Also, INR was positively correlated with the severity of IVH (Spearman's correlation coefficient: 0.193; p = 0.003). While overall fibrinogen levels were not associated with IVH, a fibrinogen level < 100 mg/dL significantly increased the risk for IVH (p < 0.01). Conclusions: Our data provide a robust set of reference values for both cellular and humoral coagulation studies in VLBW and ELBW infants for the first 24 h of life. The results of our study indicate that abnormal INR levels and fibrinogen levels < 100 mg/dL are significantly associated with the occurrence of IVH in this susceptible cohort. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Duppre, Perrine UNSPECIFIED UNSPECIFIED UNSPECIFIED Sauer, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Giannopoulou, Eleni Z. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gortner, Ludwig UNSPECIFIED UNSPECIFIED UNSPECIFIED Nunold, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagenpfeil, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Geisel, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Stephan, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-385131
DOI:	10.1016/j.earlhumdev.2015.09.008
Journal or Publication Title:	Early Hum. Dev.
Volume:	91
Number:	12
Page Range:	S. 695 - 701
Date:	2015
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-6232
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTENSIVE-CARE-UNIT; SEVERE INTRAVENTRICULAR HEMORRHAGE; EXTREMELY PRETERM INFANTS; BIRTH-WEIGHT INFANTS; FRESH-FROZEN PLASMA; PREMATURE-INFANTS; RISK-FACTORS; INTRACRANIAL HEMORRHAGE; PERINATAL EVENTS; COAGULOPATHY Multiple languages Obstetrics & Gynecology; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38513