Schuler-Thurner, B., Bartz-Schmidt, K. -U., Bornfeld, N., Cursiefen, C., Fuisting, B., Grisanti, S., Heindl, L. M., Holbach, L., Keserue, M., Knorr, H., Koch, K., Kruse, F., Meiller, R., Metz, C., Meyer-ter-Vehn, T., Much, M., Reinsberg, M., Schliep, S., Seitz, B., Schuler, G., Suesskind, D., Viestenz, A., Wagenfeld, L. and Zeschnigk, M. (2015). Immunotherapy of uveal melanoma: vaccination against cancer. Multicenter adjuvant phase 3 vaccination study using dendritic cells laden with tumor RNA for large newly diagnosed uveal melanoma. Ophthalmologe, 112 (12). S. 1017 - 1022. NEW YORK: SPRINGER. ISSN 1433-0423

Full text not available from this repository.

Abstract

Uveal melanomas are the most common malignant tumors of the eye. With modern molecular biological diagnostic methods, such as chromosome 3 typing and gene expression analysis, these tumors can be categorized into highly aggressive (monosomy 3, class II) and less aggressive forms. This molecular biological stratification is primarily important for determining the risk of these tumors as no therapy is currently available that is able to prevent or delay metastases. A randomized study of patients with a poor prognosis (monosomy 3) is currently being carried out in order to determine whether a cancer vaccine prepared from autologous (patient's own) dendritic cells and uveal melanoma RNA can prevent or delay progression and further metastases of this extremely aggressive form of cancer. Inclusion in the uveal melanoma study, which hopes to provide a potential therapeutic option for patients, is only possible if patients are referred to an institution that is able to manufacture and provide this vaccination before the patient is operated on or treated with radiation. Untreated tumor material is necessary for producing the vaccine on an individualized patient basis.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schuler-Thurner, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartz-Schmidt, K. -U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bornfeld, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cursiefen, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuisting, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grisanti, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heindl, L. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holbach, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keserue, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knorr, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koch, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kruse, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meiller, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metz, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer-ter-Vehn, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Much, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reinsberg, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schliep, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seitz, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuler, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suesskind, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viestenz, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagenfeld, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeschnigk, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-385197
DOI: 10.1007/s00347-015-0162-z
Journal or Publication Title: Ophthalmologe
Volume: 112
Number: 12
Page Range: S. 1017 - 1022
Date: 2015
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1433-0423
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
THERAPYMultiple languages
OphthalmologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38519

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item