Universität zu Köln

El Majdoub, Faycal, Neudorfer, Clemens, Blau, Tobias, Hellmich, Martin, Buehrle, Christian, Deckert, Martina, Sturm, Volker and Maarouf, Mohammad (2015). Stereotactic interstitial brachytherapy for the treatment of oligodendroglial brain tumors. Strahlenther. Onkol., 191 (12). S. 936 - 945. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-099X

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Abstract

Purpose We evaluated the treatment of oligodendroglial brain tumors with interstitial brachytherapy (IBT) using (125)iodine seeds (I-125) and analyzed prognostic factors. Patients and methods Between January 1991 and December 2010, 63 patients (median age 43.3 years, range 20.8-63.4 years) suffering from oligodendroglial brain tumors were treated with I-125 IBT either as primary, adjuvantly after incomplete resection, or as salvage therapy after tumor recurrence. Possible prognostic factors influencing disease progression and survival were retrospectively investigated. Results The actuarial 2-, 5-, and 10-year overall and progression-free survival rates after IBT for WHO II tumors were 96.9, 96.9, 89.8 % and 96.9, 93.8, 47.3 %; for WHO III tumors 90.3, 77, 54.9 % and 80.6, 58.4, 45.9 %, respectively. Magnetic resonance imaging demonstrated complete remission in 2 patients, partial remission in 13 patients, stable disease in 17 patients and tumor progression in 31 patients. Median time to progression for WHO II tumors was 87.6 months and for WHO III tumors 27.8 months. Neurological status improved in 10 patients and remained stable in 20 patients, while 9 patients deteriorated. There was no treatment-related mortality. Treatment-related morbidity was transient in 11 patients. WHO II, KPS >= 90 %, frontal location, and tumor surface dose > 50 Gy were associated with increased overall survival (p <= 0.05). Oligodendroglioma and frontal location were associated with a prolonged progression-free survival (p <= 0.05). Conclusion Our study indicates that IBT achieves local control rates comparable to surgery and radio-/chemotherapy treatment, is minimally invasive, and safe. Due to the low rate of side effects, IBT may represent an attractive option as part of a multimodal treatment schedule, being supplementary to microsurgery or as a salvage therapy after chemotherapy and conventional irradiation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code El Majdoub, Faycal UNSPECIFIED UNSPECIFIED UNSPECIFIED Neudorfer, Clemens UNSPECIFIED UNSPECIFIED UNSPECIFIED Blau, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Buehrle, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckert, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Sturm, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-385491
DOI:	10.1007/s00066-015-0887-2
Journal or Publication Title:	Strahlenther. Onkol.
Volume:	191
Number:	12
Page Range:	S. 936 - 945
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-099X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOW-GRADE GLIOMA; PHASE-III TRIAL; IMPLANTED I-125 SEEDS; ANAPLASTIC OLIGODENDROGLIOMA; EUROPEAN ORGANIZATION; PROGNOSTIC-FACTORS; RADIATION-THERAPY; MALIGNANT GLIOMAS; PCV CHEMOTHERAPY; RANDOMIZED-TRIAL Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38549