Universität zu Köln

Salama, Mahmoud ORCID: 0000-0002-0282-8018 and Woodruff, Teresa K. (2015). New advances in ovarian autotransplantation to restore fertility in cancer patients. Cancer Metastasis Rev., 34 (4). S. 807 - 823. DORDRECHT: SPRINGER. ISSN 1573-7233

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Abstract

Human ovary autotransplantation is a promising option for fertility preservation of young women and girls undergoing gonadotoxic treatments for cancer or some autoimmune diseases. Although experimental, it resulted in at least 42 healthy babies worldwide. According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic literature review was performed for all relevant full-text articles published in English from 1 January 2000 to 01 October 2015 in PubMed to explore the latest clinical and research advances of human ovary autotransplantation. Human ovary autotransplantation involves ovarian tissue extraction, freezing/thawing, and transplantation back into the same patient. Three major forms of human ovary autotransplantation exist including (a) transplantation of cortical ovarian tissue, (b) transplantation of whole ovary, and (c) transplantation of ovarian follicles (artificial ovary). According to the recent guidelines, human ovary autotransplantation is still considered experimental; however, it has unique advantages in comparison to other options of female fertility preservation. Human ovary autotransplantation (i) does not need prior ovarian stimulation, (ii) allows immediate initiation of cancer therapy, (iii) can restore both endocrine and reproductive ovarian functions, and (iv) may be the only fertility preservation option suitable for prepubertal girls or for young women with estrogen-sensitive malignancies. As any other fertility preservation option, human ovary autotransplantation has both advantages and disadvantages and may not be feasible for all cases. The major challenges facing this option are how to avoid the risk of reintroducing malignant cells and how to prolong the lifespan of ovarian transplant as well as how to improve artificial ovary results.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Salama, Mahmoud UNSPECIFIED orcid.org/0000-0002-0282-8018 UNSPECIFIED Woodruff, Teresa K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-385786
DOI:	10.1007/s10555-015-9600-2
Journal or Publication Title:	Cancer Metastasis Rev.
Volume:	34
Number:	4
Page Range:	S. 807 - 823
Date:	2015
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-7233
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IN-VITRO MATURATION; PRE-ANTRAL FOLLICLES; TISSUE CRYOPRESERVATION; LIVE BIRTH; WHOLE OVARY; OOCYTE MATURATION; ADOLESCENT PATIENTS; AMERICAN-SOCIETY; FEMALE-PATIENTS; YOUNG-WOMEN Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38578