Universität zu Köln

Granert, Oliver ORCID: 0000-0002-0656-1023, Drzezga, Alexander E., Boecker, Henning, Perneczky-, Robert, Kurz, Alexander, Goetz, Julia, van Eimeren, Thilo ORCID: 0000-0002-6951-2325 and Haeussermann, Peter (2015). Metabolic Topology of Neurodegenerative Disorders: Influence of Cognitive and Motor Deficits. J. Nucl. Med., 56 (12). S. 1916 - 1922. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

Parkinson disease with and without dementia (PDD and PD, respectively), dementia with Lewy bodies (DLB), and Alzheimer dementia (AD) traditionally have been viewed as distinct clinical and pathologic entities. However, intriguing overlaps in biochemical, clinical, and imaging findings question the concept of distinct entities and suggest a continuous spectrum in which individual patients express PD-typical patterns and AD-typical patterns to a variable degree. Methods: Following this concept, we built a topological map based on regional patterns of the cerebral metabolic rate of glucose as measured with F-18-FDG PET to rank and localize single subjects' disease status according to PD-typical (PD vs. controls) and AD-typical (AD vs. controls) pattern expression in patients clinically characterized as PD, PDD, DLB, amnestic mild cognitive impairment, and AD. Results: The topology generally confirmed an indivisible spectrum of disease manifestation according to 2 separable expression patterns. The expression values derived from the first pattern were highly correlated with individual cognitive, but not motor, disability. The opposite was found for the corresponding expression values of the second pattern. Conclusion: The metabolic imaging analysis supports the notion that there is a continuous spectrum of neurodegeneration between AD and PD. Furthermore, PDD and DLB may in fact represent 1 overlapping disease entity, characterized by the presence of mixed neuropathology and only different by the time course.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Granert, Oliver UNSPECIFIED orcid.org/0000-0002-0656-1023 UNSPECIFIED Drzezga, Alexander E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boecker, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Perneczky-, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurz, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Goetz, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED orcid.org/0000-0002-6951-2325 UNSPECIFIED Haeussermann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386185
DOI:	10.2967/jnumed.115.156067
Journal or Publication Title:	J. Nucl. Med.
Volume:	56
Number:	12
Page Range:	S. 1916 - 1922
Date:	2015
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CEREBRAL GLUCOSE-METABOLISM; LEWY BODY DEMENTIA; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; FDG-PET; EMISSION-TOMOGRAPHY; CLINICAL-DIAGNOSIS; ALPHA-SYNUCLEIN; BLOOD-FLOW; IMPAIRMENT Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38618