Universität zu Köln

Urbach, H., Rauer, S., Mader, I., Paus, S., Wagner, J., Malter, M. P., Pruess, H., Lewerenz, J., Kassubek, J., Hegen, H., Auer, M., Deisenhammer, F., Ufer, F., Bien, C. G. and Baumgartner, A. (2015). Supratentorial white matter blurring associated with voltage-gated potassium channel-complex limbic encephalitis. Neuroradiology, 57 (12). S. 1203 - 1210. NEW YORK: SPRINGER. ISSN 1432-1920

Full text not available from this repository.

Abstract

Limbic encephalitis (LE) associated with voltage-gated potassium channel-complex antibodies (VGKC-LE) is frequently non-paraneoplastic and associated with marked improvement following corticosteroid therapy. Mesial temporal lobe abnormalities are present in around 80 % of patients. If associated or preceded by faciobrachial dystonic seizures, basal ganglia signal changes may occur. In some patients, blurring of the supratentorial white matter on T2-weighted images (SWMB) may be seen. The purpose of this study was to evaluate the incidence of SWMB and whether it is specific for VGKC-LE. Two experienced neuroradiologists independently evaluated signal abnormalities on FLAIR MRI in 79 patients with LE while unaware on the antibody type. SWMB was independently assessed as present in 10 of 36 (28 %) compared to 2 (5 %) of 43 non-VGKC patients (p = 0.009). It was not related to the presence of LGI1 or CASPR2 proteins of VGKC antibodies. MRI showed increased temporomesial FLAIR signal in 22 (61 %) VGKC compared to 14 (33 %) non-VGKC patients (p = 0.013), and extratemporomesial structures were affected in one VGKC (3 %) compared to 11 (26 %) non-VGKC patients (p = 0.005). SWMB is a newly described MRI sign rather specific for VGKC-LE.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Urbach, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rauer, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mader, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paus, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Malter, M. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pruess, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewerenz, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hegen, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Auer, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Deisenhammer, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ufer, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bien, C. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumgartner, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386303
DOI:	10.1007/s00234-015-1581-x
Journal or Publication Title:	Neuroradiology
Volume:	57
Number:	12
Page Range:	S. 1203 - 1210
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1920
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FACIOBRACHIAL DYSTONIC SEIZURES; INACTIVATED 1 PROTEIN; LEUCINE-RICH; MRI FINDINGS; ANTIBODIES; LGI1; IMMUNOTHERAPY; FORM Multiple languages Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38630