Universität zu Köln

El-Khatib, Mustafa, El Majdoub, Faycal, Hunsche, Stefan, Hoevels, Mauritius, Kocher, Martin, Sturm, Volker and Maarouf, Mohammad (2015). Stereotactic LINAC radiosurgery for the treatment of typical intracranial meningiomas. Strahlenther. Onkol., 191 (12). S. 921 - 928. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-099X

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Abstract

Purpose The efficacy and safety of stereotactic radiosurgery (SRS) for treatment of intracranial meningiomas has been demonstrated in numerous studies with short- and intermediate-term follow-up. In this retrospective single-center study, we present long-term outcomes of SRS performed with a linear accelerator (LINAC) for typical intracranial meningiomas. Patients and methods Between August 1990 and December 2007, 148 patients with 168 typical intracranial meningiomas were treated with stereotactic LINAC-SRS, either as primary treatment or after microsurgical resection. A median tumor surface dose of 12 Gy (range 7-20 Gy) and a median maximum dose of 24.1 Gy (range 11.3-58.6 Gy) was applied. The median target volume was 4.7 ml (range 0.2-32.8 ml, SD +/- 4.8 ml). Results Overall mean radiological follow-up was 12.6 years. Tumor shrinkage was seen in 75 (44.6 %) and stable disease in 85 (50.6 %) cases. Eight of 168 meningiomas (4.8 %) showed local tumor progression. The tumor control rate (TCR) after 5, 10, and 15 years was 93.6 % at each time point, and the progression-free survival (PSF) rates were 92, 89, and 89 %, respectively. The neurological symptoms existing prior to LINAC-SRS improved in 77 patients (59.7 %), remained unchanged in 42 (32.6 %), and deteriorated in 10 (7.8 %) patients. Conclusion Our study emphasizes the efficacy of LINAC-SRS for de novo, residual and recurrent typical intracranial meningiomas. A high long-term local TCR with a low morbidity rate could be achieved. LINAC-SRS should thus be considered as a primary treatment option, as one arm of a combined treatment approach for incompletely resected meningiomas, or as a salvage therapy for recurrences.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code El-Khatib, Mustafa UNSPECIFIED UNSPECIFIED UNSPECIFIED El Majdoub, Faycal UNSPECIFIED UNSPECIFIED UNSPECIFIED Hunsche, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoevels, Mauritius UNSPECIFIED UNSPECIFIED UNSPECIFIED Kocher, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Sturm, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386463
DOI:	10.1007/s00066-015-0880-9
Journal or Publication Title:	Strahlenther. Onkol.
Volume:	191
Number:	12
Page Range:	S. 921 - 928
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-099X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GAMMA-KNIFE RADIOSURGERY; CAVERNOUS SINUS MENINGIOMAS; SKULL BASE MENINGIOMAS; ACCELERATOR-BASED RADIOSURGERY; PETROCLIVAL MENINGIOMAS; RESECTED MENINGIOMAS; SURGICAL-TREATMENT; RADIATION-THERAPY; CRANIAL NERVES; TUMOR-CONTROL Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38646