Universität zu Köln

Zhang, Yang, Liang, Shiwei, He, Jianzheng, Bai, Yucheng, Niu, Yonggang, Tang, Xiaolong, Li, Dongqin and Chen, Qiang (2015). Oxidative stress and antioxidant status in a lizard Phrynocephalus vlangalii at different altitudes or acclimated to hypoxia. Comp. Biochem. Physiol. A-Mol. Integr. Physiol., 190. S. 9 - 15. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1531-4332

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Abstract

Oxidative stress is a major challenge for the survival of animals living on plateaus; however, lifelong exposure to high altitudes could generate certain adaptabilities which make them more tolerant to these environments. The aim of the present study was to compare the oxidative stress and antioxidant status between low altitude (LA, 2900 m) and high altitude (HA, 4200 m) populations of Phrynocephalus vlangalii. The results showed that malondialdehyde levels in the HA populations decreased significantly in the brain, but markedly increased in the muscle and had no significant difference in the liver compared to LA populations. The activity of catalase in the brain was much higher in HA than LA. Except for total antioxidant capacity and glutathione reductase, other antioxidants were similar between the two populations in livers. By contrast, the levels of most antioxidants in muscle decreased markedly with elevation. We also explored the effects of hypoxia on oxidative damage and antioxidant defenses in P. vlangalii. The lizards were acclimated in a simulated hypoxic chamber (15% O-2 and 8% O-2) for 6 weeks. The results showed that in the 8% O-2 group, the levels of malondialdehyde, catalase, glutathione and total antioxidant capacity in the brain, and malondialdehyde, catalase and superoxide dismutase in the liver were significantly higher than the 15% O-2 group. These findings indicate that in this species the oxidative stress and antioxidant capacity are subject to altitude and hypoxia and this lizard may have acquired some ability to deal with the oxidative stress. (C) 2015 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhang, Yang UNSPECIFIED UNSPECIFIED UNSPECIFIED Liang, Shiwei UNSPECIFIED UNSPECIFIED UNSPECIFIED He, Jianzheng UNSPECIFIED UNSPECIFIED UNSPECIFIED Bai, Yucheng UNSPECIFIED UNSPECIFIED UNSPECIFIED Niu, Yonggang UNSPECIFIED UNSPECIFIED UNSPECIFIED Tang, Xiaolong UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Dongqin UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Qiang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386539
DOI:	10.1016/j.cbpa.2015.08.013
Journal or Publication Title:	Comp. Biochem. Physiol. A-Mol. Integr. Physiol.
Volume:	190
Page Range:	S. 9 - 15
Date:	2015
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1531-4332
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIPID-PEROXIDATION; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; PSAMMODROMUS-ALGIRUS; SIMULATED ALTITUDE; HYPOBARIC HYPOXIA; ADAPTATION; BRAIN; SYSTEMS; MUSCLE Multiple languages Biochemistry & Molecular Biology; Physiology; Zoology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38653