Universität zu Köln

Eichenberger, Emily M., Thaden, Joshua T., Sharma-Kuinkel, Batu, Park, Lawrence P., Rude, Thomas H., Ruffin, Felicia, Hos, Nina J., Seifert, Harald, Rieg, Siegbert ORCID: 0000-0001-7493-7080, Kern, Winfried V., Lower, Steven K., Fowler, Vance G., Jr. and Kaasch, Achim J. (2015). Polymorphisms in Fibronectin Binding Proteins A and B among Staphylococcus aureus Bloodstream Isolates Are Not Associated with Arthroplasty Infection. PLoS One, 10 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background Nonsynonymous single nucleotide polymorphisms (SNPs) in fibronectin binding protein A (fnbA) of Staphylococcus aureus are associated with cardiac device infections. However, the role of fnbA SNPs in S. aureus arthroplasty infection is unknown. Methods Bloodstream S. aureus isolates from a derivation cohort of patients at a single U.S. medical center with S. aureus bacteremia (SAB) and prosthetic hip or knee arthroplasties that were infected (PJI, n = 27) or uninfected (PJU, n = 43) underwent sequencing of fnbA and fnbB. A validation cohort of S. aureus bloodstream PJI (n = 12) and PJU (n = 58) isolates from Germany also underwent fnbA and fnbB sequencing. Results Overall, none of the individual fnbA or fnbB SNPs were significantly associated with the PJI or PJU clinical groups within the derivation cohort. Similarly, none of the individual fnbA or fnbB SNPs were associated with PJI or PJU when the analysis was restricted to patients with either early SAB (i.e., bacteremia occurring <1 year after placement or manipulation of prostheses) or late SAB (i.e., bacteremia >1 year after placement or manipulation of prostheses). Conclusions In contrast to cardiac device infections, there is no association between nonsynonymous SNPs in fnbA or fnbB of bloodstream S. aureus isolates and arthroplasty infection. These results suggest that initial steps leading to S. aureus infection of cardiovascular and orthopedic prostheses may arise by distinct processes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eichenberger, Emily M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thaden, Joshua T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharma-Kuinkel, Batu UNSPECIFIED UNSPECIFIED UNSPECIFIED Park, Lawrence P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rude, Thomas H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruffin, Felicia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hos, Nina J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifert, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieg, Siegbert UNSPECIFIED orcid.org/0000-0001-7493-7080 UNSPECIFIED Kern, Winfried V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lower, Steven K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fowler, Vance G., Jr. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaasch, Achim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-386746
DOI:	10.1371/journal.pone.0141436
Journal or Publication Title:	PLoS One
Volume:	10
Number:	11
Date:	2015
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIOFILM FORMATION; FIBRINOGEN; ADHERENCE; GENES; GENOTYPE; FNBA Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38674