Universität zu Köln

Roos, Judith, Johnson, Sarah, Weddell, Sarah, Godehardt, Erhard, Schiffner, Julia, Freundl, Guenter and Gnoth, Christian (2015). Monitoring the menstrual cycle: Comparison of urinary and serum reproductive hormones referenced to true ovulation. Eur. J. Contracept. Reprod. Health Care, 20 (6). S. 438 - 451. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1473-0782

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Abstract

Objective The aim of the study was to examine relationships and interindividual variations in urinary and serum reproductive hormone levels relative to ultrasound-observed ovulation in menstrual cycles of apparently normally menstruating women.Methods This was a prospective study of normally menstruating women (no known subfertility), aged 18-40 years (n = 40), who collected daily urine samples and attended the study centre for blood samples and transvaginal ultrasound during one complete menstrual cycle. Serum luteinising hormone (LH), progesterone, estradiol, urinary LH, pregnanediol-3- glucuronide (P3G) and estrone-3-glucuronide were measured. Ultrasound was conducted by two physicians and interpreted by central expert review.Results Menstrual cycle length varied from 22 to 37 days (median 27 days). Ovulation by ultrasound ranged from day 8 to day 26 (median day 15). Serum and urinary hormone profiles showed excellent agreement. Estrogen and LH hormone peaks in urine and serum showed a range of signal characteristics across the study group before and after ovulation. The rise in estrogen and LH always occurred before ovulation; the progesterone rise from baseline always occurred after ovulation.Conclusions Urinary and serum reproductive hormones showed excellent agreement and may be used interchangeably. The beginning of the surge in serum and urinary LH was an excellent predictor of ovulation. The rise in progesterone and P3G above baseline was a consistent marker of luteinisation confirming ovulation. Both LH and progesterone surges delivered clear, sharp signals in all volunteers, allowing reliable detection and confirmation of ovulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roos, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Johnson, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Weddell, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Godehardt, Erhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffner, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Freundl, Guenter UNSPECIFIED UNSPECIFIED UNSPECIFIED Gnoth, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-387279
DOI:	10.3109/13625187.2015.1048331
Journal or Publication Title:	Eur. J. Contracept. Reprod. Health Care
Volume:	20
Number:	6
Page Range:	S. 438 - 451
Date:	2015
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1473-0782
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOLLICLE-STIMULATING-HORMONE; LUTEINIZING-HORMONE; PREGNANEDIOL GLUCURONIDE; TEMPORAL RELATIONSHIPS; FERTILITY MONITOR; EXCRETION RATES; WOMEN; PROGESTERONE; VARIABILITY; DEFINITION Multiple languages Public, Environmental & Occupational Health; Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38727