Becker, Jessica, May, Andrea, Gerges, Christian, Anders, Mario, Veits, Lothar, Weise, Katharina, Czamara, Darina, Lyros, Orestis, Manner, Hendrik, Terheggen, Grischa, Venerito, Marino ORCID: 0000-0001-8581-0974, Noder, Tania, Mayershofer, Rupert, Hofer, Jan-Hinnerk, Karch, Hans-Werner, Ahlbrand, Constantin J., Arras, Michael, Hofer, Sebastian, Mangold, Elisabeth, Heilmann-Heimbach, Stefanie ORCID: 0000-0003-1057-465X, Heinrichs, Sophie K. M., Hess, Timo, Kiesslich, Ralf, Izbicki, Jakob R., Hoelscher, Arnulf H., Bollschweiler, Elfriede, Malfertheiner, Peter, Lang, Hauke, Moehler, Markus, Lorenz, Dietmar, Mueller-Myhsok, Bertram, Ott, Katja, Schmidt, Thomas ORCID: 0000-0002-7166-3675, Whiteman, David C., Vaughan, Thomas L., Noethen, Markus M., Hackelsberger, Andreas, Schumacher, Brigitte, Pech, Oliver, Vashist, Yogesh, Vieth, Michael, Weismueller, Josef, Neuhaus, Horst, Roesch, Thomas, Ell, Christian, Gockel, Ines and Schumacher, Johannes ORCID: 0000-0001-9217-6457 (2015). Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma. Cancer Med., 4 (11). S. 1700 - 1705. HOBOKEN: WILEY-BLACKWELL. ISSN 2045-7634

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Abstract

The Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) recently performed a genome-wide association study (GWAS) on esophageal adenocarcinoma (EAC) and Barrett's esophagus. They identified genome-wide significant association for variants at three genes, namely CRTC1, FOXP1, and BARX1. Furthermore, they replicated an association at the FOXF1 gene that has been previously found in a GWAS on Barrett's esophagus. We aimed at further replicating the association at these and other loci that showed suggestive association with P< 10(-4) in the BEACON sample. In total, we tested 88 SNPs in an independent sample consisting of 1065 EAC cases and 1019 controls of German descent. We could replicate the association at FOXP1, BARX1, and FOXF1 with nominal significance and thereby confirm that genetic variants at these genes confer EAC risk. In addition, we found association of variants near the genes XRCC2 and GATA6 that were strongly (P<10(-5)) although not genome-wide significantly associated with the BEACON GWAS. Therefore, both variants and corresponding genes represent promising candidates for future EAC association studies on independent samples.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Becker, JessicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
May, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerges, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anders, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Veits, LotharUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weise, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czamara, DarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lyros, OrestisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manner, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Terheggen, GrischaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Venerito, MarinoUNSPECIFIEDorcid.org/0000-0001-8581-0974UNSPECIFIED
Noder, TaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayershofer, RupertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofer, Jan-HinnerkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karch, Hans-WernerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahlbrand, Constantin J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arras, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofer, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mangold, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heilmann-Heimbach, StefanieUNSPECIFIEDorcid.org/0000-0003-1057-465XUNSPECIFIED
Heinrichs, Sophie K. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hess, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiesslich, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Izbicki, Jakob R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoelscher, Arnulf H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bollschweiler, ElfriedeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malfertheiner, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, HaukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moehler, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorenz, DietmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Myhsok, BertramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ott, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, ThomasUNSPECIFIEDorcid.org/0000-0002-7166-3675UNSPECIFIED
Whiteman, David C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vaughan, Thomas L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noethen, Markus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hackelsberger, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schumacher, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pech, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vashist, YogeshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vieth, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weismueller, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhaus, HorstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roesch, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ell, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gockel, InesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schumacher, JohannesUNSPECIFIEDorcid.org/0000-0001-9217-6457UNSPECIFIED
URN: urn:nbn:de:hbz:38-387773
DOI: 10.1002/cam4.500
Journal or Publication Title: Cancer Med.
Volume: 4
Number: 11
Page Range: S. 1700 - 1705
Date: 2015
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 2045-7634
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BARRETTS-ESOPHAGUS; CANCER; ASSOCIATIONMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38777

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