Jakobshagen, Kristin, Ward, Beate, Baschuk, Nikola, Huss, Sebastian, Brunn, Anna, Malecki, Monika, Fiolka, Michael, Rappl, Gunther, Corogeanu, Diana, Karow, Ulrike, Schiller, Petra, Abken, Hinrich, Heukamp, Lukas C., Deckert, Martina, Kroenke, Martin and Utermoehlen, Olaf (2015). Endogenous Il10 Alleviates the Systemic Antiviral Cellular Immune Response and T Cell-Mediated Immunopathology in Select Organs of Acutely LCMV-Infected Mice. Am. J. Pathol., 185 (11). S. 3025 - 3039. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1525-2191
Full text not available from this repository.Abstract
The immunoregulatory cytokine IL-10 suppresses T-cell immunity. The complementary question, whether IL-10 is also involved in Limiting the collateral damage of vigorous T cell responses, has not been addressed in detail. Here, we report that the particularly strong virus-specific immune response during acute primary infection with the Lymphocytic choriomeningitis virus (LCMV) in mice is significantly further increased in Il10 deficient mice, particularly regarding frequencies and cytotoxic activity of CD8(+) T cells. This increase results in exacerbating immunopathology in select organs, ranging from transient local swelling to an increased risk for mortality. Remarkably, LCMV-induced, T cell mediated hepatitis is not affected by endogenous Il10. The alleviating effect of Il10 on LCMV-induced immunopathology was found to be operative in delayed-type hypersensitivity footpad-swelling reaction and in debilitating meningitis in mice of both the C57BL/6 and BALB/c strains. These strains are prototypic counterpoles for genetically imprinted type 1-biased versus type 2-biased T cell mediated immune responses against various infectious pathogens. However, during acute LCMV infection, neither systemic cytokine patterns nor the impact of Il10 on LCMV-induced immunopathology differed conspicuously between these two strains of mice. This study documents a physiological role of Il10 in the regulation of a balanced T-cell response limiting immunopathological damage.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| URN: | urn:nbn:de:hbz:38-388090 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1016/j.ajpath.2015.07.019 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Am. J. Pathol. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Volume: | 185 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number: | 11 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Page Range: | S. 3025 - 3039 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Date: | 2015 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Publisher: | ELSEVIER SCIENCE INC | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Place of Publication: | NEW YORK | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1525-2191 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| URI: | http://kups.ub.uni-koeln.de/id/eprint/38809 |
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