Universität zu Köln

Manegold-Brauer, Gwendolin ORCID: 0000-0003-4292-6779, Bourdil, Lucas, Berg, Christoph, Schoetzau, Andreas, Gembruch, Ulrich ORCID: 0000-0001-8284-4669 and Geipel, Annegret (2015). Prenasal thickness to nasal bone length ratio in normal and trisomy 21 fetuses at 11-14 weeks of gestation. Prenat. Diagn., 35 (11). S. 1079 - 1085. HOBOKEN: WILEY-BLACKWELL. ISSN 1097-0223

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Abstract

ObjectiveTo show the feasibility and to create a reference range for prenasal thickness (PT) and for the PT to nasal bone length (NBL) ratio in normal fetuses at 11-14 gestational weeks and to compare the findings to fetuses with trisomy 21. MethodPT, NBL and PT/NBL ratio were measured retrospectively in stored two-dimensional images of 1155 normal fetuses and 44 fetuses with trisomy 21. Mid-sagittal images were acquired at first trimester ultrasound examinations and were selected from our digital database. ResultsThe PT increased with CRL from 1.0mm at 45-mm CRL to 1.6mm at 84-mm CRL. The mean PT/NBL ratio was 0.6 and was not altered by CRL. The mean PT/NBL ratio in fetuses with trisomy 21 was significantly higher than in normal fetuses (p<0.0001). For a cut-off value of 0.8 the PT/NBL yielded a sensitivity of 86.4% and a specificity of 98.4% for trisomy 21. ConclusionThe assessment of PT between 11 and 14 gestational weeks is feasible with high intraclass correlation. The PT to NBL ratio seems to be a promising marker for trisomy 21 in the first trimester and was superior to the isolated contribution of NBL and PT measurements. (c) 2015 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Manegold-Brauer, Gwendolin UNSPECIFIED orcid.org/0000-0003-4292-6779 UNSPECIFIED Bourdil, Lucas UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoetzau, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED Geipel, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-388287
DOI:	10.1002/pd.4649
Journal or Publication Title:	Prenat. Diagn.
Volume:	35
Number:	11
Page Range:	S. 1079 - 1085
Date:	2015
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1097-0223
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOWN-SYNDROME; ULTRASOUND; 2ND-TRIMESTER; 2ND; HYPOPLASIA; ABSENCE; MARKER Multiple languages Genetics & Heredity; Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38828