Manegold-Brauer, Gwendolin ORCID: 0000-0003-4292-6779, Bourdil, Lucas, Berg, Christoph, Schoetzau, Andreas, Gembruch, Ulrich ORCID: 0000-0001-8284-4669 and Geipel, Annegret (2015). Prenasal thickness to nasal bone length ratio in normal and trisomy 21 fetuses at 11-14 weeks of gestation. Prenat. Diagn., 35 (11). S. 1079 - 1085. HOBOKEN: WILEY-BLACKWELL. ISSN 1097-0223

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Abstract

ObjectiveTo show the feasibility and to create a reference range for prenasal thickness (PT) and for the PT to nasal bone length (NBL) ratio in normal fetuses at 11-14 gestational weeks and to compare the findings to fetuses with trisomy 21. MethodPT, NBL and PT/NBL ratio were measured retrospectively in stored two-dimensional images of 1155 normal fetuses and 44 fetuses with trisomy 21. Mid-sagittal images were acquired at first trimester ultrasound examinations and were selected from our digital database. ResultsThe PT increased with CRL from 1.0mm at 45-mm CRL to 1.6mm at 84-mm CRL. The mean PT/NBL ratio was 0.6 and was not altered by CRL. The mean PT/NBL ratio in fetuses with trisomy 21 was significantly higher than in normal fetuses (p<0.0001). For a cut-off value of 0.8 the PT/NBL yielded a sensitivity of 86.4% and a specificity of 98.4% for trisomy 21. ConclusionThe assessment of PT between 11 and 14 gestational weeks is feasible with high intraclass correlation. The PT to NBL ratio seems to be a promising marker for trisomy 21 in the first trimester and was superior to the isolated contribution of NBL and PT measurements. (c) 2015 John Wiley & Sons, Ltd.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Manegold-Brauer, GwendolinUNSPECIFIEDorcid.org/0000-0003-4292-6779UNSPECIFIED
Bourdil, LucasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoetzau, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gembruch, UlrichUNSPECIFIEDorcid.org/0000-0001-8284-4669UNSPECIFIED
Geipel, AnnegretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-388287
DOI: 10.1002/pd.4649
Journal or Publication Title: Prenat. Diagn.
Volume: 35
Number: 11
Page Range: S. 1079 - 1085
Date: 2015
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1097-0223
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DOWN-SYNDROME; ULTRASOUND; 2ND-TRIMESTER; 2ND; HYPOPLASIA; ABSENCE; MARKERMultiple languages
Genetics & Heredity; Obstetrics & GynecologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38828

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