Universität zu Köln

Seyffert, Michael ORCID: 0000-0001-7483-2430, Glauser, Daniel L., Tobler, Kurt, Georgiev, Oleg, Vogel, Rebecca, Vogt, Bernd, Agundez, Leticia, Linden, Michael, Buening, Hildegard, Ackermann, Mathias and Fraefel, Cornel ORCID: 0000-0001-7221-6706 (2015). Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome. J. Virol., 89 (21). S. 11150 - 11159. WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 1098-5514

Full text not available from this repository.

Abstract

Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep helicase activity can inhibit replication of any DNA if binding is facilitated. Therefore, we hypothesize that inhibition of HSV-1 replication involves direct binding of Rep68/Rep78 to the HSV-1 genome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Seyffert, Michael UNSPECIFIED orcid.org/0000-0001-7483-2430 UNSPECIFIED Glauser, Daniel L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tobler, Kurt UNSPECIFIED UNSPECIFIED UNSPECIFIED Georgiev, Oleg UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogel, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogt, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Agundez, Leticia UNSPECIFIED UNSPECIFIED UNSPECIFIED Linden, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Buening, Hildegard UNSPECIFIED UNSPECIFIED UNSPECIFIED Ackermann, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Fraefel, Cornel UNSPECIFIED orcid.org/0000-0001-7221-6706 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-388455
DOI:	10.1128/JVI.01370-15
Journal or Publication Title:	J. Virol.
Volume:	89
Number:	21
Page Range:	S. 11150 - 11159
Date:	2015
Publisher:	AMER SOC MICROBIOLOGY
Place of Publication:	WASHINGTON
ISSN:	1098-5514
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EUKARYOTIC DNA-REPLICATION; E2A GENE-EXPRESSION; INFECTED-CELLS; ADENOVIRUS REPLICATION; PREREPLICATIVE SITES; MCM HELICASE; WILD-TYPE; IN-VITRO; S-PHASE; PROTEIN Multiple languages Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38845