Guo, Xingyi, Long, Jirong
ORCID: 0000-0002-7433-9766, Zeng, Chenjie
ORCID: 0000-0002-0149-5661, Michailidou, Kyriaki
ORCID: 0000-0001-7065-1237, Ghoussaini, Maya, Bolla, Manjeet K., Wang, Qin, Milne, Roger L., Shu, Xiao-Ou, Cai, Qiuyin, Beesley, Jonathan
ORCID: 0000-0003-1942-325X, Kar, Siddhartha P.
ORCID: 0000-0002-2314-1426, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker
ORCID: 0000-0001-9320-8684, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Blot, William, Bogdanova, Natalia, Bojesen, Stig E., Brauch, Hiltrud
ORCID: 0000-0001-7531-2736, Brenner, Hermann
ORCID: 0000-0002-6129-1572, Brinton, Louise, Broeks, Annegien, Bruening, Thomas, Burwinkel, Barbara, Cai, Hui, Canisius, Sander, Chang-Claude, Jenny, Choi, Ji-Yeob, Couch, Fergus J., Cox, Angela
ORCID: 0000-0002-5138-1099, Cross, Simon S., Czene, Kamila, Darabi, Hatef, Devilee, Peter
ORCID: 0000-0002-8023-2009, Droit, Arnaud
ORCID: 0000-0001-7922-790X, Doerk, Thilo, Fasching, Peter A., Fletcher, Olivia
ORCID: 0000-0001-9387-7116, Flyger, Henrik, Fostira, Florentia, Gaborieau, Valerie, Garcia-Closas, Montserrat, Giles, Graham G., Grip, Mervi, Guenel, Pascal
ORCID: 0000-0002-8359-518X, Haiman, Christopher A., Hamann, Ute, Hartman, Mikael
ORCID: 0000-0001-5726-9965, Hollestelle, Antoinette
ORCID: 0000-0003-1166-1966, Hopper, John L., Hsiung, Chia-Ni, Ito, Hidemi, Jakubowska, Anna
ORCID: 0000-0002-5650-0501, Johnson, Nichola, Kabisch, Maria, Kang, Daehee
ORCID: 0000-0003-4031-5878, Khan, Sofia
ORCID: 0000-0003-4185-8882, Knight, Julia A., Kosma, Veli-Matti, Lambrechts, Diether
ORCID: 0000-0002-3429-302X, Le Marchand, Loic, Li, Jingmei
ORCID: 0000-0001-8587-7511, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan
ORCID: 0000-0003-2931-3003, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Marme, Frederik, Matsuo, Keitaro
ORCID: 0000-0003-1761-6314, McLean, Catriona A., Meindl, Alfons, Muir, Kenneth, Neuhausen, Susan L., Nevanlinna, Heli, Nord, Silje
ORCID: 0000-0002-3271-5356, Olson, Janet E., Orr, Nick, Peterlongo, Paolo
ORCID: 0000-0001-6951-6855, Putti, Thomas Choudary, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J., Schmidt, Marjanka K., Schmutzler, Rita K., Shen, Chen-Yang, Shi, Jiajun, Shrubsole, Martha J., Southey, Melissa C., Swerdlow, Anthony
ORCID: 0000-0001-5550-4159, Teo, Soo Hwang, Thienpont, Bernard
ORCID: 0000-0002-8772-6845, Toland, Amanda Ewart, Tollenaar, Robert A. E. M., Tomlinson, Ian P. M., Truong, Therese
ORCID: 0000-0002-2943-6786, Tseng, Chiu-chen, van den Ouweland, Ans, Wen, Wanqing, Winqvist, Robert, Wu, Anna, Yip, Cheng Har, Zamora, M. Pilar, Zheng, Ying, Hall, Per, Pharoah, Paul D. P., Simard, Jacques, Chenevix-Trench, Georgia
ORCID: 0000-0002-1878-2587, Dunning, Alison M., Easton, Douglas F. and Zheng, Wei
ORCID: 0000-0003-1226-070X
(2015).
Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk.
Cancer Epidemiol. Biomarkers Prev., 24 (11).
S. 1680 - 1692.
PHILADELPHIA:
AMER ASSOC CANCER RESEARCH.
ISSN 1538-7755
Full text not available from this repository.
Abstract
Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 x 10(-4); OR, 1.04; 95% confidence interval (CI), 1.02-1.07] and rs77928427 (P = 1.86 x 10(-4); OR, 1.04; 95% CI, 1.02-1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r(2) >= 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor-binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue. Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk. (C) 2015 AACR.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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Guo, Xingyi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Long, Jirong | UNSPECIFIED | orcid.org/0000-0002-7433-9766 | UNSPECIFIED | Zeng, Chenjie | UNSPECIFIED | orcid.org/0000-0002-0149-5661 | UNSPECIFIED | Michailidou, Kyriaki | UNSPECIFIED | orcid.org/0000-0001-7065-1237 | UNSPECIFIED | Ghoussaini, Maya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bolla, Manjeet K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang, Qin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Milne, Roger L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shu, Xiao-Ou | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cai, Qiuyin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Beesley, Jonathan | UNSPECIFIED | orcid.org/0000-0003-1942-325X | UNSPECIFIED | Kar, Siddhartha P. | UNSPECIFIED | orcid.org/0000-0002-2314-1426 | UNSPECIFIED | Andrulis, Irene L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Anton-Culver, Hoda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Arndt, Volker | UNSPECIFIED | orcid.org/0000-0001-9320-8684 | UNSPECIFIED | Beckmann, Matthias W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Beeghly-Fadiel, Alicia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Benitez, Javier | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Blot, William | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bogdanova, Natalia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bojesen, Stig E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brauch, Hiltrud | UNSPECIFIED | orcid.org/0000-0001-7531-2736 | UNSPECIFIED | Brenner, Hermann | UNSPECIFIED | orcid.org/0000-0002-6129-1572 | UNSPECIFIED | Brinton, Louise | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Broeks, Annegien | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bruening, Thomas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Burwinkel, Barbara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cai, Hui | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Canisius, Sander | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chang-Claude, Jenny | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Choi, Ji-Yeob | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Couch, Fergus J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cox, Angela | UNSPECIFIED | orcid.org/0000-0002-5138-1099 | UNSPECIFIED | Cross, Simon S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Czene, Kamila | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Darabi, Hatef | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Devilee, Peter | UNSPECIFIED | orcid.org/0000-0002-8023-2009 | UNSPECIFIED | Droit, Arnaud | UNSPECIFIED | orcid.org/0000-0001-7922-790X | UNSPECIFIED | Doerk, Thilo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fasching, Peter A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fletcher, Olivia | UNSPECIFIED | orcid.org/0000-0001-9387-7116 | UNSPECIFIED | Flyger, Henrik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fostira, Florentia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gaborieau, Valerie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Garcia-Closas, Montserrat | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Giles, Graham G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Grip, Mervi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guenel, Pascal | UNSPECIFIED | orcid.org/0000-0002-8359-518X | UNSPECIFIED | Haiman, Christopher A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hamann, Ute | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hartman, Mikael | UNSPECIFIED | orcid.org/0000-0001-5726-9965 | UNSPECIFIED | Hollestelle, Antoinette | UNSPECIFIED | orcid.org/0000-0003-1166-1966 | UNSPECIFIED | Hopper, John L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hsiung, Chia-Ni | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ito, Hidemi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jakubowska, Anna | UNSPECIFIED | orcid.org/0000-0002-5650-0501 | UNSPECIFIED | Johnson, Nichola | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kabisch, Maria | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kang, Daehee | UNSPECIFIED | orcid.org/0000-0003-4031-5878 | UNSPECIFIED | Khan, Sofia | UNSPECIFIED | orcid.org/0000-0003-4185-8882 | UNSPECIFIED | Knight, Julia A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kosma, Veli-Matti | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lambrechts, Diether | UNSPECIFIED | orcid.org/0000-0002-3429-302X | UNSPECIFIED | Le Marchand, Loic | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Li, Jingmei | UNSPECIFIED | orcid.org/0000-0001-8587-7511 | UNSPECIFIED | Lindblom, Annika | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lophatananon, Artitaya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lubinski, Jan | UNSPECIFIED | orcid.org/0000-0003-2931-3003 | UNSPECIFIED | Mannermaa, Arto | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Manoukian, Siranoush | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Margolin, Sara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Marme, Frederik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Matsuo, Keitaro | UNSPECIFIED | orcid.org/0000-0003-1761-6314 | UNSPECIFIED | McLean, Catriona A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Meindl, Alfons | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Muir, Kenneth | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Neuhausen, Susan L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nevanlinna, Heli | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nord, Silje | UNSPECIFIED | orcid.org/0000-0002-3271-5356 | UNSPECIFIED | Olson, Janet E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Orr, Nick | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Peterlongo, Paolo | UNSPECIFIED | orcid.org/0000-0001-6951-6855 | UNSPECIFIED | Putti, Thomas Choudary | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rudolph, Anja | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sangrajrang, Suleeporn | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sawyer, Elinor J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmidt, Marjanka K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmutzler, Rita K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shen, Chen-Yang | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shi, Jiajun | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shrubsole, Martha J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Southey, Melissa C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Swerdlow, Anthony | UNSPECIFIED | orcid.org/0000-0001-5550-4159 | UNSPECIFIED | Teo, Soo Hwang | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Thienpont, Bernard | UNSPECIFIED | orcid.org/0000-0002-8772-6845 | UNSPECIFIED | Toland, Amanda Ewart | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tollenaar, Robert A. E. M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tomlinson, Ian P. M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Truong, Therese | UNSPECIFIED | orcid.org/0000-0002-2943-6786 | UNSPECIFIED | Tseng, Chiu-chen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | van den Ouweland, Ans | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wen, Wanqing | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Winqvist, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wu, Anna | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yip, Cheng Har | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zamora, M. Pilar | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zheng, Ying | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hall, Per | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pharoah, Paul D. P. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Simard, Jacques | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chenevix-Trench, Georgia | UNSPECIFIED | orcid.org/0000-0002-1878-2587 | UNSPECIFIED | Dunning, Alison M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Easton, Douglas F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zheng, Wei | UNSPECIFIED | orcid.org/0000-0003-1226-070X | UNSPECIFIED |
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URN: |
urn:nbn:de:hbz:38-388601 |
DOI: |
10.1158/1055-9965.EPI-15-0363 |
Journal or Publication Title: |
Cancer Epidemiol. Biomarkers Prev. |
Volume: |
24 |
Number: |
11 |
Page Range: |
S. 1680 - 1692 |
Date: |
2015 |
Publisher: |
AMER ASSOC CANCER RESEARCH |
Place of Publication: |
PHILADELPHIA |
ISSN: |
1538-7755 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
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GENOME-WIDE ASSOCIATION; CELL SELF-RENEWAL; SUSCEPTIBILITY LOCI; MYELOID CANCERS; FUNCTIONAL VARIANTS; STEM-CELLS; CYCLIN D1; TET2; EXPRESSION; ENHANCERS | Multiple languages | Oncology; Public, Environmental & Occupational Health | Multiple languages |
|
URI: |
http://kups.ub.uni-koeln.de/id/eprint/38860 |
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