Marenholz, Ingo, Esparza-Gordillo, Jorge, Rueschendorf, Franz, Bauerfeind, Anja, Strachan, David P., Spycher, Ben D., Baurecht, Hansjoerg, Margaritte-Jeannin, Patricia, Saaf, Annika, Kerkhof, Marjan, Ege, Markus ORCID: 0000-0001-6643-3923, Baltic, Svetlana, Matheson, Melanie C., Li, Jin, Michel, Sven, Ang, Wei Q., McArdle, Wendy, Arnold, Andreas, Homuth, Georg, Demenais, Florence ORCID: 0000-0001-8361-0936, Bouzigon, Emmanuelle ORCID: 0000-0001-5756-4286, Soderhall, Cilla, Pershagen, Goran, de Jongste, Johan C., Postma, Dirkje S., Braun-Fahrlaender, Charlotte, Horak, Elisabeth, Ogorodova, Ludmila M., Puzyrev, Valery P., Bragina, Elena Yu, Hudson, Thomas J., Morin, Charles, Duffy, David L., Marks, Guy B. ORCID: 0000-0002-8976-8053, Robertson, Colin F., Montgomery, Grant W., Musk, Bill, Thompson, Philip J., Martin, Nicholas G., James, Alan, Sleiman, Patrick, Toskala, Elina, Rodriguez, Elke ORCID: 0000-0003-3692-3950, Foelster-Holst, Regina, Franke, Andre ORCID: 0000-0003-1530-5811, Lieb, Wolfgang, Gieger, Christian ORCID: 0000-0001-6986-9554, Heinzmann, Andrea, Rietschel, Ernst, Keil, Thomas, Cichon, Sven ORCID: 0000-0002-9475-086X, Noethen, Markus M., Pennell, Craig E., Sly, Peter D., Schmidt, Carsten O., Matanovic, Anja, Schneider, Valentin, Heinig, Matthias ORCID: 0000-0002-5612-1720, Huebner, Norbert, Holt, Patrick G., Lau, Susanne ORCID: 0000-0002-5189-4265, Kabesch, Michael, Weidinger, Stefan, Hakonarson, Hakon, Ferreira, Manuel A. R., Laprise, Catherine ORCID: 0000-0001-5526-9945, Freidin, Maxim B., Genuneit, Jon, Koppelman, Gerard H., Melen, Erik, Dizier, Marie-Helene ORCID: 0000-0001-8460-7667, Henderson, A. John and Lee, Young Ae (2015). Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nat. Commun., 6. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P = 2.1 x 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P = 5.3 x 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Marenholz, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esparza-Gordillo, JorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueschendorf, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauerfeind, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strachan, David P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spycher, Ben D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baurecht, HansjoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Margaritte-Jeannin, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saaf, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kerkhof, MarjanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ege, MarkusUNSPECIFIEDorcid.org/0000-0001-6643-3923UNSPECIFIED
Baltic, SvetlanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matheson, Melanie C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, JinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michel, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ang, Wei Q.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McArdle, WendyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arnold, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Homuth, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demenais, FlorenceUNSPECIFIEDorcid.org/0000-0001-8361-0936UNSPECIFIED
Bouzigon, EmmanuelleUNSPECIFIEDorcid.org/0000-0001-5756-4286UNSPECIFIED
Soderhall, CillaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pershagen, GoranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Jongste, Johan C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Postma, Dirkje S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun-Fahrlaender, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horak, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ogorodova, Ludmila M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puzyrev, Valery P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bragina, Elena YuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hudson, Thomas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morin, CharlesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duffy, David L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marks, Guy B.UNSPECIFIEDorcid.org/0000-0002-8976-8053UNSPECIFIED
Robertson, Colin F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montgomery, Grant W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Musk, BillUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thompson, Philip J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, Nicholas G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
James, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sleiman, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toskala, ElinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez, ElkeUNSPECIFIEDorcid.org/0000-0003-3692-3950UNSPECIFIED
Foelster-Holst, ReginaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, AndreUNSPECIFIEDorcid.org/0000-0003-1530-5811UNSPECIFIED
Lieb, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gieger, ChristianUNSPECIFIEDorcid.org/0000-0001-6986-9554UNSPECIFIED
Heinzmann, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rietschel, ErnstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keil, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cichon, SvenUNSPECIFIEDorcid.org/0000-0002-9475-086XUNSPECIFIED
Noethen, Markus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pennell, Craig E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sly, Peter D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Carsten O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matanovic, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, ValentinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinig, MatthiasUNSPECIFIEDorcid.org/0000-0002-5612-1720UNSPECIFIED
Huebner, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holt, Patrick G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lau, SusanneUNSPECIFIEDorcid.org/0000-0002-5189-4265UNSPECIFIED
Kabesch, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weidinger, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hakonarson, HakonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferreira, Manuel A. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laprise, CatherineUNSPECIFIEDorcid.org/0000-0001-5526-9945UNSPECIFIED
Freidin, Maxim B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Genuneit, JonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koppelman, Gerard H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Melen, ErikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dizier, Marie-HeleneUNSPECIFIEDorcid.org/0000-0001-8460-7667UNSPECIFIED
Henderson, A. JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Young AeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-388918
DOI: 10.1038/ncomms9804
Journal or Publication Title: Nat. Commun.
Volume: 6
Date: 2015
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
JUVENILE MYOCLONIC EPILEPSY; FOOD ALLERGY; FILAGGRIN MUTATIONS; BIRTH COHORT; HAY-FEVER; GENOMEWIDE ASSOCIATION; CHROMOSOME 11Q13; CHILDHOOD ASTHMA; DERMATITIS; RISKMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/38891

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