Universität zu Köln

Tschampa, Henriette J., Urbach, Horst, Traeber, Frank, Sprinkart, Alois M., Greschus, Susanne, Malter, Michael P., Surges, Rainer ORCID: 0000-0002-3177-8582, Gieseke, Juergen and Block, Wolfgang (2015). Proton magnetic resonance spectroscopy in focal cortical dysplasia at 3 T. Seizure, 32. S. 23 - 30. LONDON: W B SAUNDERS CO LTD. ISSN 1532-2688

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Abstract

Purpose: Focal cortical dysplasia (FCD) type II is a frequent cause of medically intractable epilepsy. On conventional MRI diagnosis may be difficult. The purpose of our study was to assess the metabolic characteristics of MRI-typical or neuropathologically confirmed FCD II lesions at 3 T. Methods: In a prospective study, 13 patients with drug-resistant epilepsy and MRI diagnosis of FCD II (seven neuropathologically confirmed) were investigated by single-volume proton magnetic resonance spectroscopy (H-1 MRS). We performed an intra-individual comparison placing spectroscopic volumes of interest in the lesion and in the apparently normal contralateral hemisphere. Spectroscopic results were correlated with clinical data. Results: Matched pair analysis revealed a significant increase in absolute choline (Cho) concentration in the lesion volume (+32%, p = 0.015) compared to the control volume. This increase was associated with a significant decrease in N-acetyl-aspartate (NAA) concentration (-13%; p = 0.008). Mean myo-inositol (Ins) levels were distinctly (+36%) but not significantly (p = 0.051) elevated. Lesional creatine (Cr) concentration correlated significantly with the frequency of seizures (Spearman-Rho r = 0.898; p = 0.002), while concentrations of NAA, Cho and Ins did not correlate with clinical or imaging parameters. Conclusion: MR spectroscopy revealed a characteristic metabolic pattern in FCD II lesions that helps to distinguish normal from epileptogenic tissue. (C) 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tschampa, Henriette J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Urbach, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Traeber, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Sprinkart, Alois M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Greschus, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Malter, Michael P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Surges, Rainer UNSPECIFIED orcid.org/0000-0002-3177-8582 UNSPECIFIED Gieseke, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Block, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-389062
DOI:	10.1016/j.seizure.2015.08.008
Journal or Publication Title:	Seizure
Volume:	32
Page Range:	S. 23 - 30
Date:	2015
Publisher:	W B SAUNDERS CO LTD
Place of Publication:	LONDON
ISSN:	1532-2688
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TEMPORAL-LOBE EPILEPSY; MR SPECTROSCOPY; DEVELOPMENTAL MALFORMATIONS; MULTIPLE-SCLEROSIS; FEATURES; SUBTYPES; QUANTIFICATION; CLASSIFICATION; DYSFUNCTION; CHILDREN Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38906