Universität zu Köln

Rahe, Julia, Becker, Jutta, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Kessler, Josef, Kukolja, Juraj ORCID: 0000-0003-1569-3287, Rahn, Andreas, Rosen, Jan B., Szabados, Florian, Wirth, Brunhilde ORCID: 0000-0003-4051-5191 and Kalbe, Elke (2015). Cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success. Front. Aging Neurosci., 7. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1663-4365

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Abstract

Data is inconsistent concerning the question whether cognitive-physical training (CPT) yields stronger cognitive gains than cognitive training (CT). Effects of additional counseling, neurobiological mechanisms, and predictors have scarcely been studied. Healthy older adults were trained with CT (n = 20), CPT (n = 25), or CPT with counseling (CPT+C; n = 23). Cognition, physical fitness, BDNF, IGF-1, and VEGF were assessed at pre- and post-test. No interaction effects were found except for one effect showing that CPT+C led to stronger gains in verbal fluency than CPT (p = 0.03). However, this superiority could not be assigned to additional physical training gains. Low baseline cognitive performance and BDNF, not carrying apoE4, gains in physical fitness and the moderation of gains in physical fitness X gains in BDNF predicted training success. Although all types of interventions seem successful to enhance cognition, our data do not support the hypotheses that CPT shows superior CT gains compared to CT or that CPT+C adds merit to CPT. However, as CPT leads to additional gains in physical fitness which in turn is known to have positive impact on cognition in the long-term, CPT seems more beneficial. Training success can partly be predicted by neuropsychological, neurobiological, and genetic parameters. Unique Identifier: WHO ICTRP (http://www.who.int/ictrp); ID: DRKS00005194.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rahe, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Jutta UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Kessler, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Kukolja, Juraj UNSPECIFIED orcid.org/0000-0003-1569-3287 UNSPECIFIED Rahn, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosen, Jan B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Szabados, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirth, Brunhilde UNSPECIFIED orcid.org/0000-0003-4051-5191 UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-389876
DOI:	10.3389/fnagi.2015.00187
Journal or Publication Title:	Front. Aging Neurosci.
Volume:	7
Date:	2015
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1663-4365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUROTROPHIC FACTOR BDNF; RANDOMIZED-CONTROLLED-TRIAL; AGE-DIFFERENCES; MENTAL ACTIVITY; AGING BRAIN; EXERCISE; INTERVENTIONS; IMPAIRMENT; PLASTICITY; DISEASE Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38987