Troilo, Helen ORCID: 0000-0003-0537-1786, Barrett, Anne L., Wohl, Alexander P., Jowitt, Thomas A., Collins, Richard F., Bayley, Christopher P., Zuk, Alexandra V., Sengle, Gerhard and Baldock, Clair ORCID: 0000-0003-3497-1959 (2015). The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity. Biochem. Soc. Trans., 43. S. 795 - 801. LONDON: PORTLAND PRESS LTD. ISSN 1470-8752

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Abstract

Chordin-mediated regulation of bone morphogenetic protein (BMP) family growth factors is essential in early embryogenesis and adult homoeostasis. Chordin binds to BMPs through cysteine-rich von Willebrand factor type C (vWC) homology domains and blocks them from interacting with their cell surface receptors. These domains also self-associate and enable chordin to target related proteins to fine-tune BMP regulation. The chordin-BMP inhibitory complex is strengthened by the secreted glycoprotein twisted gastrulation (Tsg); however, inhibition is relieved by cleavage of chordin at two specific sites by tolloid family metalloproteases. As Tsg enhances this cleavage process, it serves a dual role as both promoter and inhibitor of BMP signalling. Recent developments in chordin research suggest that rather than simply being by-products, the cleavage fragments of chordin continue to play a role in BMP regulation. In particular, chordin cleavage at the C-terminus potentiates its anti-BMP activity in a type-specific manner.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Troilo, HelenUNSPECIFIEDorcid.org/0000-0003-0537-1786UNSPECIFIED
Barrett, Anne L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wohl, Alexander P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jowitt, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collins, Richard F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayley, Christopher P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuk, Alexandra V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sengle, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldock, ClairUNSPECIFIEDorcid.org/0000-0003-3497-1959UNSPECIFIED
URN: urn:nbn:de:hbz:38-391861
DOI: 10.1042/BST20150071
Journal or Publication Title: Biochem. Soc. Trans.
Volume: 43
Page Range: S. 795 - 801
Date: 2015
Publisher: PORTLAND PRESS LTD
Place of Publication: LONDON
ISSN: 1470-8752
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BONE MORPHOGENETIC PROTEIN; TWISTED GASTRULATION; INHIBITOR; PROMOTES; BINDING; DOMAINMultiple languages
Biochemistry & Molecular BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39186

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