Universität zu Köln

Stauss, Hans J., Morris, Emma C. and Abken, Hinrich (2015). Cancer gene therapy with T cell receptors and chimeric antigen receptors. Curr. Opin. Pharmacol., 24. S. 113 - 119. OXFORD: ELSEVIER SCI LTD. ISSN 1471-4973

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Abstract

Viral and non-viral gene transfer technologies have been used to efficiently generate therapeutic T cells with desired cancer-specificity. Chimeric antigen receptors (CARs) redirect T cell specificity toward antibody-recognized antigens expressed on the surface of cancer cells, while T cell receptors (TCRs) extend the range of targets to include intracellular tumor antigens. CAR redirected T cells specific for the B cell differentiation antigen CD19 have shown dramatic efficacy in the treatment of B cell malignancies, while TCR-redirected T cells have shown benefits in patients suffering from solid cancer. In this review we will present strategies to optimize CAR and TCR function, and discuss the importance of target antigen selection to enhance tumor specificity, while reducing on-target and off-target toxicity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stauss, Hans J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morris, Emma C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Abken, Hinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-391951
DOI:	10.1016/j.coph.2015.08.006
Journal or Publication Title:	Curr. Opin. Pharmacol.
Volume:	24
Page Range:	S. 113 - 119
Date:	2015
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1471-4973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENHANCED ANTITUMOR-ACTIVITY; ANTI-PD-L1 ANTIBODY; IMMUNE RECEPTORS; TCR; REGRESSION; IMMUNOTHERAPY; ACTIVATION; EFFICACY; CD28; IMMUNORECEPTORS Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39195