Universität zu Köln

Rahe, Julia, Liesk, Jennifer, Rosen, Jan B., Petrelli, Annette, Kaesberg, Stephanie, Onur, Oezguer A., Kessler, Josef, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Kalbe, Elke (2015). Sex differences in cognitive training effects of patients with amnestic mild cognitive impairment. Aging Neuropsychol. Cogn., 22 (5). S. 620 - 639. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD. ISSN 1744-4128

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Abstract

Cognitive training has been shown to be effective in improving cognitive functions in patients with Mild Cognitive Impairment (MCI). However, data on factors that may influence training gains including sociodemographic variables such as sex or age is rare. In this study, the impact of sex on cognitive training effects was examined in N=32 age- and education-matched female (n=16) and male (n=16) amnestic MCI patients (total sample: age M=74.97, SD=5.21; education M=13.50, SD=3.11). Patients participated in a six-week multidomain cognitive training program including 12 sessions each 90 min twice weekly in mixed groups with both women and men. Various cognitive domains were assessed before and after the intervention. Despite comparable baseline performance in women and men, we found significant interaction effects Time x Sex in immediate (p = .04) and delayed verbal episodic memory (p= .045) as well as in working memory (p = .042) favoring the female MCI patients. In contrast, the overall analyses with the total sample did not reveal any significant within-subject effects Time. In conclusion, our results give preliminary evidence for stronger cognitive training improvements of female compared to male MCI patients. More generally, they emphasize the importance of sex-sensitive evaluations of cognitive training effects. Possible underlying mechanisms of the found sex differences are discussed and directions for future research are given.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rahe, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Liesk, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosen, Jan B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrelli, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaesberg, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kessler, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-393162
DOI:	10.1080/13825585.2015.1028883
Journal or Publication Title:	Aging Neuropsychol. Cogn.
Volume:	22
Number:	5
Page Range:	S. 620 - 639
Date:	2015
Publisher:	ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-4128
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEALTHY OLDER-ADULTS; ALZHEIMERS-DISEASE; EPISODIC MEMORY; GENDER-DIFFERENCES; VERBAL MEMORY; WORKING-MEMORY; EARLY DEMENTIA; SCREENING-TEST; RISK-FACTORS; AGE Multiple languages Psychology, Developmental; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39316