Universität zu Köln

Wessels, Helen, Wagner, Michael ORCID: 0000-0003-2589-6440, Frommann, Ingo, Berning, Julia, Puetzfeld, Verena, Janssen, Birgit, Bottlender, Ronald, Maurer, Kurt, Moeller, Hans-Juergen, Gaebel, Wolfgang, Haefner, Heinz, Maier, Wolfgang, Klosterkoetter, Joachim and Bechdolf, Andreas (2015). Neuropsychological Functioning as a Predictor of Treatment Response to Psychoeducational, Cognitive Behavioral Therapy in People at Clinical High Risk of First Episode Psychosis. Psychiatr. Prax., 42 (6). S. 313 - 320. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-0876

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Abstract

Objective: Investigate whether treatment response in people at clinical high risk of psychosis (CHR) is predicted by their cognitive performance. Method: 128 CHR outpatients were randomized into two treatment groups, one receiving integrated psychological intervention (IPI), including psychoeducation, the other receiving supportive counselling (SC) for 12 months. Multiple regression analysis was used to identify neurocognitive predictors of treatment response in a subgroup of n=105, measured by symptomatic and functional improvement at 1-year follow-up. Results: In the IPI, treatment response was associated with per formance of executive control and processing speed (R-2 = 0.27, p=0.002). In both treatment groups, performance of working memory/attention was a significant predictor (IPI: R-2 = 0.15, p=0.039, SC: R-2 = 0.19, p=0.012). Conclusion: Cognitive performance is associated with treatment response in CHR people. The enhancement of cognitive performance is a useful target of early intervention.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wessels, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Frommann, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Berning, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Puetzfeld, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Janssen, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Bottlender, Ronald UNSPECIFIED UNSPECIFIED UNSPECIFIED Maurer, Kurt UNSPECIFIED UNSPECIFIED UNSPECIFIED Moeller, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaebel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Haefner, Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechdolf, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-393894
DOI:	10.1055/s-0035-1552713
Journal or Publication Title:	Psychiatr. Prax.
Volume:	42
Number:	6
Page Range:	S. 313 - 320
Date:	2015
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-0876
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SCHIZOPHRENIA; 1ST-EPISODE; INTERVENTION; PERFORMANCE; PREVENTION; DISORDERS; SYMPTOMS; PRODROME; DEFICITS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39389