Universität zu Köln

Volz, Lukas J. ORCID: 0000-0002-0161-654X, Hamada, Masashi ORCID: 0000-0002-2866-8067, Rothwell, John C. and Grefkes, Christian ORCID: 0000-0002-1656-720X (2015). What Makes the Muscle Twitch: Motor System Connectivity and TMS-Induced Activity. Cereb. Cortex, 25 (9). S. 2346 - 2354. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) evokes several volleys of corticospinal activity. While the earliest wave (D-wave) originates from axonal activation of corticospinal neurons (CSN), later waves (I-waves) result from activation of mono-and polysynaptic inputs to CSNs. Different coil orientations preferentially stimulate cortical elements evoking different outputs: latero-medial-induced current (LM) elicits D-waves and short-latency electromyographic responses (MEPs); posterior-anterior current (PA) evokes early I-waves. Anterior-posterior current (AP) is more variable and tends to recruit later I-waves, featuring longer onset latencies compared with PA-TMS. We tested whether the variability in response to AP-TMS was related to functional connectivity of the stimulated M1 in 20 right-handed healthy subjects who underwent functional magnetic resonance imaging while performing an isometric contraction task. The MEP-latency after AP-TMS (relative to LM-TMS) was strongly correlated with functional connectivity between the stimulated M1 and a network involving cortical premotor areas. This indicates that stronger premotor-M1 connectivity increases the probability that AP-TMS recruits shorter latency input to CSNs. In conclusion, our data strongly support the hypothesis that TMS of M1 activates distinct neuronal pathways depending on the orientation of the stimulation coil. Particularly, AP currents seem to recruit short latency cortico-cortical projections from premotor areas.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Volz, Lukas J. UNSPECIFIED orcid.org/0000-0002-0161-654X UNSPECIFIED Hamada, Masashi UNSPECIFIED orcid.org/0000-0002-2866-8067 UNSPECIFIED Rothwell, John C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-394174
DOI:	10.1093/cercor/bhu032
Journal or Publication Title:	Cereb. Cortex
Volume:	25
Number:	9
Page Range:	S. 2346 - 2354
Date:	2015
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1460-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; DORSAL PREMOTOR CORTEX; FUNCTIONAL CONNECTIVITY; CORTICOSPINAL VOLLEYS; CORTICAL PLASTICITY; BRAIN-STIMULATION; VENTRAL PREMOTOR; CONSCIOUS HUMANS; UNIT RESPONSES; SURFACE EMG Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39417