Universität zu Köln

Seeger-Nukpezah, Tamina, Geynisman, Daniel M., Nikonova, Anna S., Benzing, Thomas and Golemis, Erica A. (2015). The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease. Nat. Rev. Nephrol., 11 (9). S. 515 - 535. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1759-507X

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Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a progressive inherited disorder in which renal tissue is gradually replaced with fluid-filled cysts, giving rise to chronic kidney disease (CKD) and progressive loss of renal function. ADPKD is also associated with liver ductal cysts, hypertension, chronic pain and extra-renal problems such as cerebral aneurysms. Intriguingly, improved understanding of the signalling and pathological derangements characteristic of ADPKD has revealed marked similarities to those of solid tumours, even though the gross presentation of tumours and the greater morbidity and mortality associated with tumour invasion and metastasis would initially suggest entirely different disease processes. The commonalities between ADPKD and cancer are provocative, particularly in the context of recent preclinical and clinical studies of ADPKD that have shown promise with drugs that were originally developed for cancer. The potential therapeutic benefit of such repurposing has led us to review in detail the pathological features of ADPKD through the lens of the defined, classic hallmarks of cancer. In addition, we have evaluated features typical of ADPKD, and determined whether evidence supports the presence of such features in cancer cells. This analysis, which places pathological processes in the context of defined signalling pathways and approved signalling inhibitors, highlights potential avenues for further research and therapeutic exploitation in both diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Seeger-Nukpezah, Tamina UNSPECIFIED UNSPECIFIED UNSPECIFIED Geynisman, Daniel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nikonova, Anna S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Golemis, Erica A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-394694
DOI:	10.1038/nrneph.2015.46
Journal or Publication Title:	Nat. Rev. Nephrol.
Volume:	11
Number:	9
Page Range:	S. 515 - 535
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1759-507X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VON-HIPPEL-LINDAU; PLANAR CELL POLARITY; TUMOR-SUPPRESSOR GENE; TUBULAR EPITHELIAL-CELLS; OF-FUNCTION MODEL; CYST FORMATION; SIGNALING PATHWAY; PRIMARY CILIA; FIELD CANCERIZATION; GROWTH-FACTOR Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39469