Universität zu Köln

Viehmann, Anja, Hertel, Sabine, Fuks, Kateryna, Eisele, Lewin, Moebus, Susanne, Moehlenkamp, Stefan, Nonnemacher, Michael, Jakobs, Hermann, Erbel, Raimund, Joeckel, Karl-Heinz and Hoffmann, Barbara (2015). Long-term residential exposure to urban air pollution, and repeated measures of systemic blood markers of inflammation and coagulation. Occup. Environ. Med., 72 (9). S. 656 - 664. LONDON: BMJ PUBLISHING GROUP. ISSN 1470-7926

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Abstract

Background In several studies, exposure to fine particulate matter (PM) has been associated with inflammation, with inconsistent results. We used repeated measurements to examine the association of long-term fine and ultrafine particle exposure with several blood markers of inflammation and coagulation. Methods We used baseline (2000-2003) and follow-up (2006-2008) data from the Heinz Nixdorf Recall Study, a German population-based prospective cohort of 4814 participants. A chemistry transport model was applied to model daily surface concentrations of PM air pollutants (PM10, PM2.5) and particle number on a grid of 1 km(2). Applying mixed regression models, we analysed associations of long-term (mean of 365 days prior to blood draw) particle exposure at each participant's residence with the level of high-sensitivity C reactive protein (hs-CRP), fibrinogen, platelet and white cell count (WCC), adjusting for short-term PM exposure (moving averages of 1-7 days), personal characteristics, season, ambient temperature (1-5 days), ozone and time trend. Results We analysed 6488 observations: 3275 participants with baseline data and 3213 with follow-up data. An increase of 2.4 mu g/m(3) in long-term PM2.5 was associated with an adjusted increase of 5.4% (95% CI 0.6% to 10.5%) in hs-CRP and of 2.3% (95% CI 1.4% to 3.3%) in the platelet count. Fibrinogen and WCC were not associated with long-term particle exposure. Conclusions In this population-based cohort, we found associations of long-term exposure to PM with markers of inflammation (hs-CRP) and coagulation (platelets). This finding supports the hypothesis that inflammatory processes might contribute to chronic effects of air pollution on cardiovascular disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Viehmann, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Hertel, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuks, Kateryna UNSPECIFIED UNSPECIFIED UNSPECIFIED Eisele, Lewin UNSPECIFIED UNSPECIFIED UNSPECIFIED Moebus, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Moehlenkamp, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Nonnemacher, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakobs, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Erbel, Raimund UNSPECIFIED UNSPECIFIED UNSPECIFIED Joeckel, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-395147
DOI:	10.1136/oemed-2014-102800
Journal or Publication Title:	Occup. Environ. Med.
Volume:	72
Number:	9
Page Range:	S. 656 - 664
Date:	2015
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1470-7926
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language C-REACTIVE PROTEIN; PARTICULATE MATTER; RISK; ACTIVATION; POLLUTANTS; FIBRINOGEN; DISEASE Multiple languages Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39514