Universität zu Köln

Galldiks, Norbert ORCID: 0000-0002-2485-1796, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Filss, Christian ORCID: 0000-0002-9927-6335, Rapp, Marion, Blau, Tobias, Tscherpel, Caroline, Ceccon, Garry, Dunkl, Veronika, Weinzierl, Martin, Stoffel, Michael, Sabel, Michael, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Shah, Nadim J. and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2015). The use of dynamic O-(2-F-18-fluoroethyl)-l-tyrosine PET in the diagnosis of patients with progressive and recurrent glioma. Neuro-Oncology, 17 (9). S. 1293 - 1301. CARY: OXFORD UNIV PRESS INC. ISSN 1523-5866

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Abstract

We evaluated the diagnostic value of static and dynamic O-(2-[F-18]fluoroethyl)-l-tyrosine (F-18-FET) PET parameters in patients with progressive or recurrent glioma. We retrospectively analyzed 132 dynamic F-18-FET PET and conventional MRI scans of 124 glioma patients (primary World Health Organization grade II, n = 55; grade III, n = 19; grade IV, n = 50; mean age, 52 +/- 14 y). Patients had been referred for PET assessment with clinical signs and/or MRI findings suggestive of tumor progression or recurrence based on Response Assessment in Neuro-Oncology criteria. Maximum and mean tumor/brain ratios of F-18-FET uptake were determined (20-40 min post-injection) as well as tracer uptake kinetics (ie, time to peak and patterns of the time-activity curves). Diagnoses were confirmed histologically (95%) or by clinical follow-up (5%). Diagnostic accuracies of PET and MR parameters for the detection of tumor progression or recurrence were evaluated by receiver operating characteristic analyses/chi-square test. Tumor progression or recurrence could be diagnosed in 121 of 132 cases (92%). MRI and F-18-FET PET findings were concordant in 84% and discordant in 16%. Compared with the diagnostic accuracy of conventional MRI to diagnose tumor progression or recurrence (85%), a higher accuracy (93%) was achieved by F-18-FET PET when a mean tumor/brain ratio a parts per thousand yen2.0 or time to peak < 45 min was present (sensitivity, 93%; specificity, 100%; accuracy, 93%; positive predictive value, 100%; P < .001). Static and dynamic F-18-FET PET parameters differentiate progressive or recurrent glioma from treatment-related nonneoplastic changes with higher accuracy than conventional MRI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Filss, Christian UNSPECIFIED orcid.org/0000-0002-9927-6335 UNSPECIFIED Rapp, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Blau, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Tscherpel, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Ceccon, Garry UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunkl, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Weinzierl, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-395783
DOI:	10.1093/neuonc/nov088
Journal or Publication Title:	Neuro-Oncology
Volume:	17
Number:	9
Page Range:	S. 1293 - 1301
Date:	2015
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1523-5866
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; RADIATION NECROSIS; FET PET; C-11-METHIONINE PET; UPTAKE KINETICS; F-18-FET PET; TUMOR; PSEUDOPROGRESSION; DIFFERENTIATION; SPECT Multiple languages Oncology; Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39578