Dyverfeldt, Petter ORCID: 0000-0002-3051-661X, Bissell, Malenka ORCID: 0000-0002-1282-2859, Barker, Alex J., Bolger, Ann F., Carlhall, Carl-Johan ORCID: 0000-0003-2198-9690, Ebbers, Tino ORCID: 0000-0003-1395-8296, Francios, Christopher J., Frydrychowicz, Alex ORCID: 0000-0002-6559-5565, Geiger, Julia, Giese, Daniel ORCID: 0000-0002-3925-4441, Hope, Michael D., Kilner, Philip J., Kozerke, Sebastian ORCID: 0000-0003-3725-8884, Myerson, Saul ORCID: 0000-0001-5927-0230, Neubauer, Stefan, Wieben, Oliver ORCID: 0000-0002-7931-1930 and Markl, Michael (2015). 4D flow cardiovascular magnetic resonance consensus statement. J. Cardiov. Magn. Reson., 17. LONDON: BMC. ISSN 1532-429X

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Abstract

Pulsatile blood flow through the cavities of the heart and great vessels is time-varying and multidirectional. Access to all regions, phases and directions of cardiovascular flows has formerly been limited. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) has enabled more comprehensive access to such flows, with typical spatial resolution of 1.5x1.5x1.5 - 3x3x3 mm(3), typical temporal resolution of 30-40 ms, and acquisition times in the order of 5 to 25 min. This consensus paper is the work of physicists, physicians and biomedical engineers, active in the development and implementation of 4D Flow CMR, who have repeatedly met to share experience and ideas. The paper aims to assist understanding of acquisition and analysis methods, and their potential clinical applications with a focus on the heart and greater vessels. We describe that 4D Flow CMR can be clinically advantageous because placement of a single acquisition volume is straightforward and enables flow through any plane across it to be calculated retrospectively and with good accuracy. We also specify research and development goals that have yet to be satisfactorily achieved. Derived flow parameters, generally needing further development or validation for clinical use, include measurements of wall shear stress, pressure difference, turbulent kinetic energy, and intracardiac flow components. The dependence of measurement accuracy on acquisition parameters is considered, as are the uses of different visualization strategies for appropriate representation of time-varying multidirectional flow fields. Finally, we offer suggestions for more consistent, user-friendly implementation of 4D Flow CMR acquisition and data handling with a view to multicenter studies and more widespread adoption of the approach in routine clinical investigations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dyverfeldt, PetterUNSPECIFIEDorcid.org/0000-0002-3051-661XUNSPECIFIED
Bissell, MalenkaUNSPECIFIEDorcid.org/0000-0002-1282-2859UNSPECIFIED
Barker, Alex J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bolger, Ann F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carlhall, Carl-JohanUNSPECIFIEDorcid.org/0000-0003-2198-9690UNSPECIFIED
Ebbers, TinoUNSPECIFIEDorcid.org/0000-0003-1395-8296UNSPECIFIED
Francios, Christopher J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frydrychowicz, AlexUNSPECIFIEDorcid.org/0000-0002-6559-5565UNSPECIFIED
Geiger, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giese, DanielUNSPECIFIEDorcid.org/0000-0002-3925-4441UNSPECIFIED
Hope, Michael D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilner, Philip J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kozerke, SebastianUNSPECIFIEDorcid.org/0000-0003-3725-8884UNSPECIFIED
Myerson, SaulUNSPECIFIEDorcid.org/0000-0001-5927-0230UNSPECIFIED
Neubauer, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieben, OliverUNSPECIFIEDorcid.org/0000-0002-7931-1930UNSPECIFIED
Markl, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-396558
DOI: 10.1186/s12968-015-0174-5
Journal or Publication Title: J. Cardiov. Magn. Reson.
Volume: 17
Date: 2015
Publisher: BMC
Place of Publication: LONDON
ISSN: 1532-429X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WALL SHEAR-STRESS; PHASE-CONTRAST MRI; BICUSPID AORTIC-VALVE; IN-VIVO VALIDATION; PULSE-WAVE VELOCITY; K-T BLAST; TURBULENT KINETIC-ENERGY; PROSTHETIC HEART-VALVES; MAIN PULMONARY-ARTERY; BLOOD-FLOWMultiple languages
Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39655

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