Shaabani, Namir, Honke, Nadine, Dolff, Sebastian ORCID: 0000-0001-5549-1706, Goerg, Boris, Khairnar, Vishal ORCID: 0000-0002-3584-7530, Merches, Katja, Duhan, Vikas ORCID: 0000-0002-6337-8225, Metzger, Sabine, Recher, Mike ORCID: 0000-0002-9121-6936, Barthuber, Carmen, Hardt, Cornelia, Proksch, Peter, Haeussinger, Dieter, Witzke, Oliver, Lang, Philipp A. and Lang, Karl S. (2015). IFN-gamma licenses CD11b(+) cells to induce progression of systemic lupus erythematosus. J. Autoimmun., 62. S. 11 - 22. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1095-9157

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Abstract

Autoantibodies are a hallmark of autoimmune diseases, such as rheumatoid arthritis, autoimmune hepatitis, and systemic lupus erythematosus (SLE). High titers of anti-nuclear antibodies are used as surrogate marker for SLE, however their contribution to pathogenesis remains unclear. Using murine model of SLE and human samples, we studied the effect of immune stimulation on relapsing of SLE. Although autoantibodies bound to target cells in vivo, only additional activation of CD8(+) T cells converted this silent autoimmunity into overt disease. In mice as well as in humans CU8(+) T cells derived IFN-gamma enhanced expression of Fc-receptors on CD11b(+) cells. High expression of Fc-receptors allowed CD11b(+) cells to bind to antibody covered target cells and to destroy them in vivo. We found that autoantibodies induce clinically relevant disease when adaptive immunity, specific for disease non-related antigen, is activated. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Shaabani, NamirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Honke, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dolff, SebastianUNSPECIFIEDorcid.org/0000-0001-5549-1706UNSPECIFIED
Goerg, BorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khairnar, VishalUNSPECIFIEDorcid.org/0000-0002-3584-7530UNSPECIFIED
Merches, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duhan, VikasUNSPECIFIEDorcid.org/0000-0002-6337-8225UNSPECIFIED
Metzger, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Recher, MikeUNSPECIFIEDorcid.org/0000-0002-9121-6936UNSPECIFIED
Barthuber, CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hardt, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Proksch, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haeussinger, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witzke, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, Philipp A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, Karl S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-397391
DOI: 10.1016/j.jaut.2015.05.007
Journal or Publication Title: J. Autoimmun.
Volume: 62
Page Range: S. 11 - 22
Date: 2015
Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication: LONDON
ISSN: 1095-9157
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LYMPHOCYTIC CHORIOMENINGITIS VIRUS; AUTOIMMUNE-DISEASE; INTERFERON-GAMMA; RECEPTOR EXPRESSION; MEMORY-PHENOTYPE; T-CELLS; IN-VIVO; AUTOANTIBODIES; NEUTROPHILS; MECHANISMSMultiple languages
ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39739

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