Universität zu Köln

Koehler, Christhardt, Oppelt, Peter, Favero, Giovanni, Morgenstern, Bernd, Runnebaum, Ingo, Tsunoda, Audrey, Schmittel, Alexander, Schneider, Achim, Mueller, Michael and Marnitz, Simone (2015). How much platinum passes the placental barrier? Analysis of platinum applications in 21 patients with cervical cancer during pregnancy. Am. J. Obstet. Gynecol., 213 (2). NEW YORK: MOSBY-ELSEVIER. ISSN 1097-6868

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Abstract

OBJECTIVE: Cervical cancer is the most common solid cancer diagnosed in pregnancy. Platinum is an active drug in the treatment of patients with cervical cancer. In the second and third trimesters, platinum is used to prevent cancer progression until fetal maturity is reached. However, knowledge about the transplacental passage of platinum is very limited. STUDY DESIGN: Between May 2008 and June 2014, platinum-based neoadjuvant chemotherapy was applied to 21 consecutive patients with cervical cancer diagnosed in their second trimester. At the time of delivery by cesarean delivery, synchronous samples from maternal blood, umbilical cord blood, and amniotic fluid were taken and analyzed for platinum concentrations. RESULTS: The mean week of gestation at cancer diagnosis was 17 (13-23). On average 3 (range, 2-4) cycles of chemotherapy were applied. Cesarean deliveries were carried out between 30.4 and 36.5 weeks of gestation. Twenty-two healthy babies without renal, hepatic, auditory, or hematopoietic impairment were delivered. Platinum concentrations in umbilical cord blood and amniotic fluid were 23-65% and 11-42% of the maternal blood, respectively. CONCLUSION: This series on in vivo measurement of platinum concentrations in the fetomaternal compartment observed that because of consistently lower platinum values in the fetoplacental unit, a placental filtration mechanism of platinum may be assumed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koehler, Christhardt UNSPECIFIED UNSPECIFIED UNSPECIFIED Oppelt, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Favero, Giovanni UNSPECIFIED UNSPECIFIED UNSPECIFIED Morgenstern, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Runnebaum, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Tsunoda, Audrey UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmittel, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Achim UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Marnitz, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-397607
DOI:	10.1016/j.ajog.2015.02.022
Journal or Publication Title:	Am. J. Obstet. Gynecol.
Volume:	213
Number:	2
Date:	2015
Publisher:	MOSBY-ELSEVIER
Place of Publication:	NEW YORK
ISSN:	1097-6868
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEOADJUVANT CHEMOTHERAPY; RADICAL HYSTERECTOMY; DELIVERY DELAY; CISPLATIN; OUTCOMES; DERIVATIVES; PROGRESSION; GUIDELINES; NEOPLASIA; CARCINOMA Multiple languages Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39760