Universität zu Köln

Caramoy, Albert, Kearns, Victoria R., Chan, Yau Kei, Hagedorn, Nadine, Poole, Robert J., Wong, David, Fauser, Sascha, Kugler, Wilfried, Kirchhof, Bernd and Williams, Rachel L. (2015). Development of emulsification resistant heavier-than-water tamponades using high molecular weight silicone oil polymers. J. Biomater. Appl., 30 (2). S. 212 - 221. LONDON: SAGE PUBLICATIONS LTD. ISSN 1530-8022

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Abstract

Purpose Developing new blends of heavier-than-water silicone oil tamponade agents containing high molecular weight polydimethylsiloxane polymer for use in vitreoretinal surgery. Materials and methods The viscoelastic properties of heavier-than-water silicone oil blends (30.5% F6H8+69.5% polydimethylsiloxane) containing high molecular weight polymer additive at increasing concentrations were measured using a controlled-stress rheometer (TA Instruments Rheolyst AR 1000N). Emulsification of the blends was induced using a sonication device and a pluronic surfactant as a strong emulsifier. The percentage emulsion area was photographed and measured using ImageJ software. In a second in vitro emulsification assessment, silicone oil blends were dispersed using a high shear homogenizer and the oil-in-water droplets were counted using a coulter counter particle analyser. Results The addition of the high molecular weight polymer increased shear viscosity and viscoelasticity of the oil blends, which were measureable and to some extent predictable. The in vitro emulsification models produced contradictory results. This demonstrates the difficulty of designing and using in vitro models to evaluate the emulsification tendency of tamponade agents in vivo. Conclusion Addition of a high molecular weight polymer to heavy silicone oil can increase the viscoelasticity. These findings might contribute to the development of emulsification resistant heavy silicone oils.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Caramoy, Albert UNSPECIFIED UNSPECIFIED UNSPECIFIED Kearns, Victoria R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chan, Yau Kei UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagedorn, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Poole, Robert J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wong, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Kugler, Wilfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Williams, Rachel L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-398115
DOI:	10.1177/0885328215575623
Journal or Publication Title:	J. Biomater. Appl.
Volume:	30
Number:	2
Page Range:	S. 212 - 221
Date:	2015
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1530-8022
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RETINAL-DETACHMENT; INTRAOCULAR TAMPONADE; COMPLICATIONS; VESICLES; LIQUIDS; MODEL Multiple languages Engineering, Biomedical; Materials Science, Biomaterials Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39811