Universität zu Köln

Bour, L. J., Ackermans, L., Foncke, E. M. J., Cath, D., van der Linden, C., Vandewalle, V. Visser and Tijssen, M. A. (2015). Tic related local field potentials in the thalamus and the effect of deep brain stimulation in Tourette syndrome: Report of three cases. Clin. Neurophysiol., 126 (8). S. 1578 - 1589. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-8952

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Abstract

Objective: Three patients with intractable Tourette syndrome (TS) underwent thalamic deep brain stimulation (DBS). To investigate the role of thalamic electrical activity in tic generation, local field potentials (LFP), EEG and EMG simultaneously were recorded. Methods: Event related potentials and event related spectral perturbations of EEG and LFP, event related cross-coherences between EEG/LFP and LFP/LFP were analyzed. As time locking events, the tic onsets were used. Spontaneous tics were compared to voluntary tic mimicking. The effect of tic suppression and DBS on thalamic LFPs was evaluated. Results: All three patients showed time-locked and prior to onset of spontaneous motor tics thalamic synchronization and thalamo-cortical cross-coherence. Also in three patients, not time-locked to motor tics, increased intra-thalamic coherences in the 1-8 Hz frequency band were found. In one patient it was demonstrated that voluntary mimicked tics were preceded by premotor cortical and thalamic potentials. In this patient unilateral thalamic DBS contralaterally decreased the background thalamic activity. Conclusions: The present study in three cases with TS shows that spontaneous tics in TS are preceded by repetitive coherent thalamo-cortical discharges, indicating that preceding a tic the basal ganglia circuits are charged up, ultimately leading to a motor tic. Significance: Thalamic LFP recording may lead to more insight in underlying pathophysiological mechanisms in TS. (c) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bour, L. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ackermans, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Foncke, E. M. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cath, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Linden, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vandewalle, V. Visser UNSPECIFIED UNSPECIFIED UNSPECIFIED Tijssen, M. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-398345
DOI:	10.1016/j.clinph.2014.10.217
Journal or Publication Title:	Clin. Neurophysiol.
Volume:	126
Number:	8
Page Range:	S. 1578 - 1589
Date:	2015
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-8952
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PARKINSONS-DISEASE; GLOBUS-PALLIDUS; NEURAL ACTIVITY; MOTOR TICS; EEG; SYNCHRONIZATION; PROJECTION; NETWORKS; COMPLEX; SURGERY Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39834